600708-96-1

Basic information

• Product Name: 4-Hexenoic acid, 6-oxo-6-[(4R)-2-oxo-4-phenyl-3-oxazolidinyl]-, 1,1-dimethylethyl ester, (4E)-
• CAS NO: 600708-96-1
• Molecular Formula: C19H23NO5
• Molecular Weight: 345.395
• Mol File: 600708-96-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Hexenoic acid, 6-oxo-6-[(4R)-2-oxo-4-phenyl-3-oxazolidinyl]-, 1,1-dimethylethyl ester, (4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hexenoic acid, 6-oxo-6-[(4R)-2-oxo-4-phenyl-3-oxazolidinyl]-, 1,1-dimethylethyl ester, (4E)-(600708-96-1)
• EPA Substance Registry System: 4-Hexenoic acid, 6-oxo-6-[(4R)-2-oxo-4-phenyl-3-oxazolidinyl]-, 1,1-dimethylethyl ester, (4E)-(600708-96-1)

Safety Data

• Hazardous Substances Data: 600708-96-1(Hazardous Substances Data)

Upstream product

• 59854-12-5 tert-butyl 4-hydroxybutyrate 
• 15026-17-2 succinic acid mono-tert-butyl ester 
• 51534-77-1 tert-butyl 4-oxo-butanoate 
• 227602-33-7 diethyl (R)-2-oxo-2-(2-oxo-4-phenyloxazolidin-3-yl)ethylphosphonate 

Downstream Products

• 600708-97-2 (4R,5S)-5-azido-4-(4-methoxyphenyl)-6-oxo-6-[(4S)-(2-oxo-4-phenyloxazolidin-3-yl)]hexanoic acid tert-butyl ester 
• 600708-99-4 (2S,3R)-2-methoxycarbonylamino-3-(4-methoxyphenyl)hexanedioic acid 6-tert-butyl ester 1-methyl ester 
• 600709-00-0 (2S,3R)-2-methoxycarbonylamino-3-(4-methoxyphenyl)hexanedioic acid 1-methyl ester 
• 600708-98-3 (2S,3R)-2-azido-3-(4-methoxyphenyl)hexanedioic acid 6-tert-butyl ester 1-methyl ester 

Relevant articles and documents

Synthesis of a new conformation-constrained L-tyrosine analogue as a potential scaffold for SH2 domain ligands

The enantioselective synthesis of a new tricyclic tyrosine analogue is reported. This conformation-contrained SH2 domain ligand scaffold 2 was designed on the basis of the natural ligand, whose structure contains the elements of a tyrosine moiety having χ1 and χ2 angles constrained to values observed for a phosphotyrosyl (pTyr) residue bound to the p56lck SH2 domain. It represents a unique, highly constrained amino acid, which may be of value in signal transduction studies. Three key steps, an asymmetric tandem Michael addition, an intramolecular Friedel-Crafts reaction, and an intramolecular Mannich reaction, were successfully applied in the presented synthetic route.