600725-16-4

Basic information

• Product Name: 4-chloro-N₂-(3-dimethylaminopropyl)-benzene-1,2-diamine
• Synonyms: 4-chloro-N₂-(3-dimethylaminopropyl)-benzene-1,2-diamine
• CAS NO: 600725-16-4
• Molecular Weight: 227.737
• Mol File: 600725-16-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-chloro-N₂-(3-dimethylaminopropyl)-benzene-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N₂-(3-dimethylaminopropyl)-benzene-1,2-diamine(600725-16-4)
• EPA Substance Registry System: 4-chloro-N₂-(3-dimethylaminopropyl)-benzene-1,2-diamine(600725-16-4)

Safety Data

• Hazardous Substances Data: 600725-16-4(Hazardous Substances Data)

Upstream product

• 109-55-7 1-amino-3-(dimethylamino)propane 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 92547-10-9 N¹-(5-chloro-2-nitrophenyl)-N³,N³-dimethylpropane-1,3-diamine 

Downstream Products

• 600724-59-2 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid [1-[6-chloro-1-(3-dimethylaminopropyl)-1H-benzimidazol-2-yl]-2-(3,4-dibromo-phenyl)-ethyl]-amide 

Relevant articles and documents

Indole RSK inhibitors. Part 2: Optimization of cell potency and kinase selectivity

A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of compound 24, BIX 02565, an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.