60090-77-9Relevant articles and documents
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Wu,T.C.,Houk,K.N.
, p. 5308 (1985)
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Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin
McErlean, Christopher S. P.,Proisy, Nicolas,Davis, Christopher J.,Boland, Nicola A.,Sharp, Swee Y.,Boxall, Kathy,Slawin, Alexandra M. Z.,Workman, Paul,Moody, Christopher J.
, p. 531 - 546 (2008/03/27)
A series of ansa-quinones has been prepared by chemical synthesis, and evaluated by biological techniques. Thus, 19-membered ansa-lactams, simplified analogues of the naturally occurring Hsp90 molecular chaperone inhibitor geldanamycin, were obtained by concise routes, the key steps being the combination of a ring-closing metathesis to give a 17-membered ring followed by Claisen rearrangement to effect ring expansion. The methodology was also used to prepare an "unnatural" 18-membered ring analogue. In ATPase enzyme assays, the synthetic ansa-quinones were weak inhibitors of Hsp90. The Royal Society of Chemistry 2007.
SUBSTITUTED 4-AMINO-1-BENZYLPIPERIDINE COMPOUNDS
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Page 81, (2008/06/13)
This invention provides 4-amino-1-benzylpiperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome, asthma and chronic obstructive pulmonary disease, using such compounds.