60091-85-2

Basic information

• Product Name: Benzene, 1-nitro-4-(3-phenylpropoxy)-
• CAS NO: 60091-85-2
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.289
• Mol File: 60091-85-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-nitro-4-(3-phenylpropoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-nitro-4-(3-phenylpropoxy)-(60091-85-2)
• EPA Substance Registry System: Benzene, 1-nitro-4-(3-phenylpropoxy)-(60091-85-2)

Safety Data

• Hazardous Substances Data: 60091-85-2(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 637-59-2 1-Bromo-3-phenylpropane 
• 122-97-4 3-Phenyl-1-propanol 
• 350-46-9 4-Fluoronitrobenzene 
• 1124-31-8 potassium 4-nitrophenolate 

Downstream Products

• 57181-86-9 4-(3'-phenylpropyloxy)aniline 

Relevant articles and documents

Synthesis and biological evaluation of novel IM3829 (4-(2-cyclohexylethoxy)aniline) derivatives as potent radiosensitizers

Nuclear factor-erythroid 2-related factor 2 (Nrf2) regulates the expression of over 200 genes of antioxidant and phase II drug-metabolizing enzymes, and is highly expressed in non-small cell lung cancer (NSCLC). Nine derivatives of 4-(2-cyclohexylethoxy)aniline were designed. Our previous study demonstrated that IM3829 increases radiosensitivity of several lung cancer cells in vitro and in vivo. Here, biological effects of IM3829 derivatives (2a-2i) were evaluated. Compound 2g derivative effectively inhibits mRNA and protein expression of Nrf2 and HO-1. In addition, we observed over two fold enhancement in IR-induced cell death, from 2.90 ± 0.22 to 6.02 ± 0.87, in H1299 cancer cell-line. Among the nine derivatives, compound 2g derivative exhibited the highest enhancement of radiosensitizing effect via inhibition of Nrf2 activity.

Multipolymer solution-phase reactions: Application to the mitsunobu reaction

The realization of the first polymer-on-polymer Mitsunobu reaction, in which a polymeric phosphine is used simultaneously with a polymeric azodicarboxylate, is reported. This strategy employs the use of soluble oligomers generated from ring-opening methathesis polymerization. 31P NMR analysis revealed that the two polymers were interacting to generate the Mitsunobu products. Application to several substrates, as well as comparison experiments with other polymeric reagents, is described. Copyright

Arylisothiocyanate for the regulation of plant growth

New arylisothiocyanates corresponding to the formula STR1 wherein R represents alkyl, alkoxy or halogen X represents oxygen or sulfur and P represents an integer of from 2 to 5 are disclosed. They can be used for the regulation of plant growth especially for the dessication and defoliation of unlignified parts of plants above the soil.