60135-71-9

Basic information

• Product Name: 5-(3,4-DIMETHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE
• Synonyms: 5-(3,4-DIMETHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE
• CAS NO: 60135-71-9
• Molecular Formula: C₁₀H₁₁N₃O₃
• Molecular Weight: 221.22
• Mol File: 60135-71-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(3,4-DIMETHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-DIMETHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE(60135-71-9)
• EPA Substance Registry System: 5-(3,4-DIMETHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE(60135-71-9)

Safety Data

• Hazardous Substances Data: 60135-71-9(Hazardous Substances Data)

Upstream product

• 506-68-3 bromocyane 
• 41764-74-3 3,4-dimethoxybenzohydrazide 
• 5346-37-2 3,4-Dimethoxybenzaldehyde semicarbazone 
• 4426-72-6 hydrazine carboxamide 
• 93-07-2 Veratric acid 
• 5346-37-2 C₁₀H₁₃N₃O₃ 
• 563-41-7 semicarbazide hydrochloride 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 19938-43-3 N-[5-(3,4-dimethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-acetamide 
• 19938-60-4 1-[5-(3,4-dimethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-3-phenyl-urea 
• 19938-56-8 5-(3,4-dimethoxy-phenyl)-3-methyl-3H-[1,3,4]oxadiazol-2-ylideneamine 
• 1335198-60-1 C₁₀H₉ClN₂O₃ 
• 1335198-55-4 1-cyclopropyl-7-(4-(5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1335198-41-8 C₂₉H₃₀FN₅O₇ 
• 1335198-48-5 C₂₆H₂₆FN₅O₆ 

Relevant articles and documents

Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety

Based on previous studies, 66 2-phenyl-4H-chromone derivatives containing amide and 1,3,4-oxadiazole moieties were prepared as potential telomerase inhibitors. The results showed most of the title compounds exhibited significantly inhibitory activity on telomerase. Among them, some compounds demonstrated the most potent telomerase inhibitory activity (IC50 50 = 6.41 μM). In addition, clear structure–activity relationships were summarised, indicating that the substitution of the methoxy group and the position, type and number of the substituents on the phenyl ring had significant effects on telomerase activity. Among them, compound A33 showed considerable inhibition against telomerase. Flow cytometric analysis showed that compound A33 could arrest MGC-803 cell cycle at G2/M phase and induce apoptosis in a concentration-dependent way. Meanwhile, Western blotting revealed that this compound could reduce the expression of dyskerin, which is a fragment of telomerase.

Electrochemical synthesis of 2-amino-5-substituted-1,3,4-oxadiazole derivatives and evaluation of antibacterial activity

Some new 2-amino-5-substituted-1,3,4-oxadiazoles have been synthesized at platinum electrode through the electrochemical oxidation of semicarbazone at room temperature and studied for their antibacterial activity. This is an environmentally benign method in the field of electroorganic synthesis under controlled potential electrolysis in an undivided cell. The electrolysis have been carried out in the acetonitrile solvent and lithium perchlorate is used as a supporting electrolyte. Two platinum plates are used as working as well as counter electrode and saturated calomel electrode as the reference electrode. These compounds have been characterized by microanalyses, IR, Mass, 1H NMR and 13C NMR spectral data. All the compounds have been evaluated for their antibacterial activity against Klebsilla penumoniae, Escherichia coli, Streptococcus aureus and Shigella dysenteriea at 25 and 50 ppm concentrations.

Facile method for the conversion of semicarbazones/thiosemicarbazones into azines (Under Microwave Irradiation) and oxadiazoles (By Grinding)

In an effective transformation, semicarbazones/thiosemicarbazones are smoothly converted into azines under microwave irradition. Oxadiazoles are also obtained from semicarbazones by reaction with bromine generated in situ via a grinding reaction in the solid phase. Taylor &Francis Group, LLC.