60135-72-0

Basic information

• Product Name: 2-(2-Amino-thiazol-4-yl)-phenol
• Synonyms: 2-(2-amino-4-thiazolyl)phenol;Phenol, 2-(2-amino-4-thiazolyl)-;JR-13976, 2-(2-Aminothiazol-4-yl)phenol, 96%
• CAS NO: 60135-72-0
• Molecular Formula: C₉H₈N₂OS
• Molecular Weight: 192.24
• Mol File: 60135-72-0.mol
• Article Data: 20

Chemical Properties

• Melting Point: 139-140 °C
• Boiling Point: 402.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.391±0.06 g/cm3(Predicted)
• PKA: 8.61±0.30(Predicted)
• CAS DataBase Reference: 2-(2-Amino-thiazol-4-yl)-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Amino-thiazol-4-yl)-phenol(60135-72-0)
• EPA Substance Registry System: 2-(2-Amino-thiazol-4-yl)-phenol(60135-72-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 60135-72-0(Hazardous Substances Data)

Usage

General Description

2-(2-Amino-thiazol-4-yl)-phenol is a compound with the molecular formula C9H8N2OS. It consists of a phenol group attached to a thiazole ring, with an amino group located at the 2-position of the thiazole ring. This chemical is used in the manufacturing of pharmaceuticals and research chemicals. It has potential applications in the development of drugs for various medical conditions, due to its unique structure and properties. 2-(2-Amino-thiazol-4-yl)-phenol may also have uses in the field of organic synthesis and materials science. Overall, this chemical has potential for various applications and is of interest to researchers and manufacturers in the pharmaceutical and chemical industries.

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 17356-08-0 thiourea 
• 2491-36-3 2-(2-bromoacetyl)hydroxybenzene 
• 90-02-8 salicylaldehyde 
• 7451-95-8 o-Hydroxyphenylacetaldehyde 

Downstream Products

• 99073-48-0 2-(2-amino-5-thiocyanato-thiazol-4-yl)-phenol 
• 108719-57-9 4-[2-amino-4-(2-hydroxy-phenyl)-thiazol-5-ylazo]-benzenesulfonic acid amide 
• 1223515-77-2 C₁₄H₉N₃O₂S₂ 
• 1458056-12-6 N-(4-(2-hydroxyphenyl)thiazol-2-yl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide 

Relevant articles and documents

Functionalized carbon dots of thiazole derivatives based on inner filter effect for tetracyclines detection

In this paper, we have developed a fluorescent probe based on thiazole derivative-functionalized carbon dots (CDs-AP) for the rapid, simple, and selective testing of commonly used antibiotics tetracyclines (TCs). Using citric acid (CA) and diethylenetriam

1-Methylimidazolium ionic liquid supported on Ni@zeolite-Y: fabrication and performance as a novel multi-functional nanocatalyst for one-pot synthesis of 2-aminothiazoles and 2-aryl benzimidazoles

In the present study, 1-methyl-3-(3-trimethoxysilylpropyl)-1H-imidazol-3-ium chloride-supported Ni@zeolite-Y-based nanoporous materials (Ni@zeolite-Im-IL) were synthesized and their structures were confirmed using different characterization techniques such as FT-IR, FE-SEM, EDX, XRD, BET and TGA-DTG analyses. In order to synthesize this multi-functional nano-system, zeolite-NaY was modified first, with exchanged Ni2+ ions and 3-chloropropyltriethoxysilane (CPTES) as a coupling reagent and then functionalized to imidazolium chloride ionic liquid by N-methylimidazole. New multi-functional nano-material of Ni@zeolite-Im-IL demonstrated high activity in the catalytic synthesis of 2-aminothiazoles 3a–l by one-pot reaction of methylcarbonyls, thiourea and iodine at 80?°C in DMSO with good to excellent yields (85–98%). Also, the catalytic synthesis of 2-aryl benzimidazoles, 6a–m was performed by the condensational reaction of o-arylendiamine and aromatic aldehydes in EtOH at room temperature with excellent yields (90–98%). Advantages of this efficient synthetic strategy include higher purity and shorter reaction time, excellent yield, easy isolation of products, the good stability, activity and feasible reusability of the metallic ionic liquid nanocatalyst. These benefits have made this method more compatible with the principles of green chemistry. Graphical abstract: [Figure not available: see fulltext.]

Design, synthesis and molecular modelling studies of 1-methyl-3-(4-substituted phenyl-1,3thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazolin-4(1h)-ones as potent anticancer agents

The present study involves the design, synthesis, characterization and molecular docking studies of biologically active quinazolin-4-ones, which were synthesized by condensing 2-amino-4-substituted phenylthiazole with N-methylbenzoxazin-4-one. The N-methylbenzoxazin-4-one and 2-amino-4-substituted phenylthiazole were synthesized from N-methylanthranilic acid and substituted ketones, respectively. The ADME properties determined the synthetic accessibility of quinazolin-4-ones by in silico Swiss ADME. The colorectal anticancer screening was done by using cell HT-29 human colorectal adenocarcinoma based on molecular docking studies on 3GC7-the structure of p38alpha in complex with dihydroquinazolinone. Finally, compounds 5Dh8, 5DF6, 5Db2 and 5Di9 exhibited better activity at a concentration 10 μg/mL when compared to 5-fluorouracil. The ADME properties revealed that all the compounds were within the range and docking studies showed the highest binding with glide score -7.19 and -7.027 Kcal/mol compared to the target protein -10.67 Kcal/mol.