60137-06-6

Basic information

• Product Name: cucurbitacins
• Synonyms: (10α,24S)-16α,24-Epoxy-2,25-dihydroxy-9β-methyl-19-norlanosta-1,5-diene-3,11,22-trione;19-Norlanosta-1,5-diene-3,11,22-trione, 16,24-epoxy-2,25-dihydroxy-9-methyl-, (9beta,10alpha,16alpha,24S)-
• CAS NO: 60137-06-6
• Molecular Formula: C30H42O6
• Molecular Weight: 498.656
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 60137-06-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 650.7 °C at 760 mmHg
• Flash Point: 208.8 °C
• Appearance: /
• Density: 1.22±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.1E-19mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: cucurbitacins(CAS DataBase Reference)
• NIST Chemistry Reference: cucurbitacins(60137-06-6)
• EPA Substance Registry System: cucurbitacins(60137-06-6)

Safety Data

• Hazardous Substances Data: 60137-06-6(Hazardous Substances Data)

Usage

Description

Cucurbitacins are a group of tetracyclic triterpenoid compounds that belong to the family of cucurbitanes. They are naturally found in various plants, including the Cucurbitaceae family, which consists of watermelons, cucumbers, and muskmelons. These compounds are known for their anti-inflammatory, anti-tumor, and antioxidant effects. Cucurbitacins serve as a defense mechanism for plants against predators, as they produce a bitter taste that deters consumption. Over time, humans have bred these fruits to reduce or eliminate the presence of cucurbitacins, resulting in more palatable produce.

Uses

Used in Pharmaceutical Industry:
Cucurbitacins are used as potential therapeutic agents for various medical applications due to their anti-inflammatory, anti-tumor, and antioxidant properties. They have shown promise in the treatment of various diseases, including cancer, inflammation, and oxidative stress-related conditions.
Used in Cancer Treatment:
Cucurbitacins are used as anti-cancer agents, particularly in the treatment of solid tumors. They have demonstrated the ability to inhibit tumor growth and proliferation by targeting multiple signaling pathways involved in cancer development and progression. Additionally, cucurbitacins have shown potential for enhancing the efficacy of conventional chemotherapeutic drugs, making them a valuable tool in overcoming drug resistance in cancer treatment.
Used in Inflammation Management:
Cucurbitacins are used as anti-inflammatory agents to manage various inflammation-related conditions. Their ability to modulate inflammatory responses and reduce the production of pro-inflammatory mediators makes them a potential therapeutic option for treating diseases characterized by chronic inflammation, such as arthritis and autoimmune disorders.
Used in Antioxidant Applications:
Cucurbitacins are used as antioxidants to protect cells from oxidative stress and damage. Their antioxidant properties help neutralize free radicals and prevent cellular damage, making them a potential candidate for the prevention and treatment of oxidative stress-related diseases, such as neurodegenerative disorders and cardiovascular diseases.
Used in Plant Defense:
In the context of plant biology, cucurbitacins serve as a natural defense mechanism against predators. The bitter taste of these compounds deters herbivores from consuming the plants, thus providing a means of protection and survival for the plant species.

InChI:InChI=1/C30H42O6/c1-15-18(31)12-23(27(4,5)35)36-20-13-28(6)21-10-9-16-17(11-19(32)25(34)26(16,2)3)30(21,8)22(33)14-29(28,7)24(15)20/h9,11,15,17,20-21,23-24,32,35H,10,12-14H2,1-8H3/t15-,17-,20-,21+,23+,24+,28+,29-,30+/m1/s1