60207-19-4

Basic information

• Product Name: 1-(4-chloro-2-methoxyphenyl)ethanone
• Synonyms: 1-(4-chloro-2-methoxyphenyl)ethanone
• CAS NO: 60207-19-4
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.61956
• Mol File: 60207-19-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-chloro-2-methoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chloro-2-methoxyphenyl)ethanone(60207-19-4)
• EPA Substance Registry System: 1-(4-chloro-2-methoxyphenyl)ethanone(60207-19-4)

Safety Data

• Hazardous Substances Data: 60207-19-4(Hazardous Substances Data)

Usage

Chemical class

Acetophenone

Physical state

White crystalline solid

Uses

Synthesis of pharmaceuticals, organic compounds, reagent in chemical reactions, building block in complex organic molecule synthesis

Molecular weight

182.62 g/mol

Hazards

Harmful if ingested or inhaled, requires caution during handling

Upstream product

• 6921-66-0 4-chloro-2-hydroxy acetophenone 
• 77-78-1 dimethyl sulfate 
• 205320-02-1 4-chloro-N,2-dimethoxy-N-methylbenzamide 
• 75-16-1 methylmagnesium bromide 
• 57479-70-6 2-methoxy-4-chlorobenzoic acid 
• 13031-39-5 3-chlorophenyl acetate 
• 3375-31-3 palladium diacetate 
• 755027-21-5 4-chloro-1-iodo-2-methoxybenzene 
• 74-88-4 methyl iodide 
• 7758-89-6 copper(I) chloride 
• 60207-18-3 4'-amino-2'-methoxylacetophenone 
• 100960-68-7 4-chloro-2-methoxylbenzonitrile 

Downstream Products

• 6921-66-0 4-chloro-2-hydroxy acetophenone 
• 114741-22-9 7-chloro-4-oxo-4H-chromene-2-carboxylic acid 
• 164026-03-3 C₁₁H₁₂ClNO₂ 
• 1354928-54-3 C₁₇H₁₁ClO₄ 
• 1354928-59-8 C₁₇H₁₁ClO₄ 
• 60208-06-2 2-bromo-2'-methoxy-4'-chloroacetophenone 

Relevant articles and documents

Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors

Using reported glutathione S-transferase omega 1 (GSTO1-1) cocrystal structures, we designed and synthesized acrylamide-containing compounds that covalently bind to Cys32 on the catalytic site. Starting from a thiazole derivative 10 (GSTO1-1 IC50 = 0.6 μM), compound 18 was synthesized and cocrystallized with GSTO1. Modification on the amide moiety of hit compound 10 significantly increased the GSTO1-1 inhibitory potency. We solved the cocrystal structures of new derivatives, 37 and 44, bearing an amide side chain bound to GSTO1. These new structures showed a reorientation of the phenyl thiazole core of inhibitors, 37 and 44, when compared to 18. Guided by the cocrystal structure of GSTO1:44, analogue 49 was designed, resulting in the most potent GSTO1-1 inhibitor (IC50 = 0.22 ± 0.02 nM) known to date. We believe that our data will form the basis for future studies of developing GSTO1-1 as a new drug target for cancer therapy.

Chromenones as potent bradykinin B1 antagonists

A series of fused 6,6-bicyclic chromenones was investigated for activity against the bradykinin B1 receptor. SAR studies based on a pharmacophore model revealed compounds with high affinity for both human and rabbit B1. These compounds demonstrated favorable pharmacokinetic properties and 5-chlorochromenone 15 was efficacious in a carrageenan-induced mechanical hyperalgesia model for chronic pain.

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.