60230-37-7 Usage
Description
2,6-Difluorobenzenesulfonamide is a fluorinated benzenesulfonamide compound that can be synthesized by reacting 2,6-difluorobenzenesulfonyl chloride with 29% ammonium hydroxide. It is known for its ability to form complexes with human carbonic anhydrase II (HCA), and the X-ray crystal structures of these complexes have been studied to understand their interactions and potential applications.
Uses
Used in Pharmaceutical Industry:
2,6-Difluorobenzenesulfonamide is used as a complexing agent for human carbonic anhydrase II (HCA) due to its ability to form stable complexes with the enzyme. This interaction is crucial for studying the enzyme's structure, function, and potential therapeutic applications in various diseases.
Used in Research and Development:
In the field of research and development, 2,6-difluorobenzenesulfonamide serves as a valuable compound for studying the interactions between small molecules and proteins, specifically human carbonic anhydrase II. The X-ray crystal structures of the complexes formed between this compound and HCA provide insights into the molecular mechanisms and potential drug design strategies for targeting carbonic anhydrase-related diseases.
Used in Chemical Synthesis:
2,6-Difluorobenzenesulfonamide can be used as a starting material or intermediate in the synthesis of various fluorinated compounds, which have applications in different industries, including pharmaceuticals, agrochemicals, and materials science. The presence of fluorine atoms in the molecule can impart unique properties to the synthesized compounds, making them valuable for a wide range of applications.
Check Digit Verification of cas no
The CAS Registry Mumber 60230-37-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,3 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 60230-37:
(7*6)+(6*0)+(5*2)+(4*3)+(3*0)+(2*3)+(1*7)=77
77 % 10 = 7
So 60230-37-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H5F2NO2S/c7-4-2-1-3-5(8)6(4)12(9,10)11/h1-3H,(H2,9,10,11)
60230-37-7Relevant articles and documents
2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE
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Page/Page column 209, (2021/06/26)
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.
Insect growth regulators. Analogues of TH-6038 and TH-6040.
Oliver,DeMilo,Cohen,Shortino,Robbins
, p. 1065 - 1068 (2007/10/10)
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