60272-64-2Relevant articles and documents
Dynamic Kinetic Resolution of Azlactones by a Chiral N, N-Dimethyl-4-aminopyridine Derivative Containing a 1,1′-Binaphthyl Unit: Importance of Amide Groups
Mandai, Hiroki,Hongo, Kohei,Fujiwara, Takuma,Fujii, Kazuki,Mitsudo, Koichi,Suga, Seiji
supporting information, p. 4811 - 4814 (2018/08/24)
A dynamic kinetic resolution (DKR) of azlactones in the presence of benzoic acid and a binaphthyl-based N,N-4-dimethylaminopyridine (DMAP) derivative 1i having two amide groups at the 3,3′-positions of a binaphthyl unit is developed. The reaction proceeded smoothly with a wide range of azlactones to provide α-amino acid derivatives with good to high enantiomeric ratios (er's). A multigram-scale reaction (2.5 g) for the DKR of azlactone 2d was also demonstrated, and the resulting product was converted to unnatural α-amino acid 6d′.
α-Hydroxymethylaspartic acid: Synthesis and absolute configuration by X-ray analysis of its derivative (+)-4-benzoylamino-4-carboxy-γ-butyrolactone
Wieczorek, Wanda,Bukowska-Strzyzewska, Maria,Olma, Aleksandra,Kaminski, Zbigniew J.,Leplawy, Miroslaw T.
, p. 107 - 112 (2007/10/02)
(+)-4-Benzoylamino-4-carboxy-γ-butyrolactone was synthesized, and its structure solved by direct methods and refined to R = 0.033.The molecule adopts a skew conformation with a C7-N1-C8-C12 torsion angle of 59.6(2) deg.The lactone ring has an envelope con