60278-33-3

Basic information

• Product Name: Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)-
• CAS NO: 60278-33-3
• Molecular Formula: C15H14O4
• Molecular Weight: 258.274
• Mol File: 60278-33-3.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)-(60278-33-3)
• EPA Substance Registry System: Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)-(60278-33-3)

Safety Data

• Hazardous Substances Data: 60278-33-3(Hazardous Substances Data)

Upstream product

• 150-19-6 O-methylresorcine 
• 156-38-7 4-hydroxyphenylacetate 
• 109-63-7 boron trifluoride diethyl etherate 
• 14191-95-8 4-cyanomethylphenol 
• 109-63-7 trifluoroborane diethyl ether 

Downstream Products

• 486-63-5 isoformononetin 
• 812646-54-1 4-[4-(4-bromo-butoxy)-benzyl]-7-methoxy-3-phenyl-chromen-2-one 
• 280137-79-3 7-methoxy-3-phenyl-4-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-chromen-2-one 
• 740810-13-3 7-methoxy-3-phenyl-4-[4-(3-piperidin-1-yl-propoxy)-benzyl]-chromen-2-one 
• 740810-14-4 7-methoxy-3-phenyl-4-[4-(4-piperidin-1-yl-butoxy)-benzyl]-chromen-2-one 
• 601513-43-3 3-(2,4-dichlorophenyl)-4-(4-hydroxybenzyl)-7-methoxy-chromen-2-one 

Relevant articles and documents

Structural modification and antihypertensive activity study of formononetin derivatives

A series of formononetin derivatives with substituted benzyloxy groups on the 4′ position of isoflavone were designed and synthesized. Their vasodilative activities were evaluated by wire myograph system on isolated rat mesenteric arterial ring. The preli

Combinatorial synthesis of structurally diverse triazole-bridged flavonoid dimers and trimers

Flavonoids are a large family of compounds associated with a broad range of biologically useful properties. In recent years, synthetic compounds that contain two flavonoid units linked together have attracted attention in drug discovery and development projects. Numerous flavonoid dimer systems, incorporating a range of monomers attached via different linkers, have been reported to exhibit interesting bioactivities. From a medicinal chemistry perspective, the 1,2,3-triazole ring system has been identified as a particularly attractive linker moiety in dimeric derivatives (owing to several favourable attributes including proven biological relevance and metabolic stability) and triazole-bridged flavonoid dimers possessing anticancer and antimalarial activities have recently been reported. However, there are relatively few examples of libraries of triazole-bridged flavonoid dimers and the diversity of flavonoid subunits present within these is typically limited. Thus, this compound type arguably remains underexplored within drug discovery. Herein, we report a modular strategy for the synthesis of novel and biologically interesting triazole-bridged flavonoid heterodimers and also very rare heterotrimers from readily available starting materials. Application of this strategy has enabled step-efficient and systematic access to a library of structurally diverse compounds of this sort, with a variety of monomer units belonging to six different structural subclasses of flavonoid successfully incorporated.

Induction of targeted osteogenesis with 3-aryl-2H-benzopyrans and 3-aryl-3H-benzopyrans: Novel osteogenic agents

Development of target oriented chemotherapeutics for treatment of chronic diseases have been considered as an important approach in drug development. Following this approach, in our efforts for exploration of new osteogenic leads, substituted 3-aryl-2H-be