603-87-2

Basic information

• Product Name: 2-amino-6-nitro-phenol
• Synonyms: 2-amino-6-nitro-phenol;NSC 87541
• CAS NO: 603-87-2
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12
• Mol File: 603-87-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: >280 °C
• Boiling Point: 280.3 °C at 760 mmHg
• Flash Point: 123.3 °C
• Appearance: /
• Density: 1.511 g/cm³
• Vapor Pressure: 0.00224mmHg at 25°C
• Refractive Index: 1.688
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 6.85±0.24(Predicted)
• CAS DataBase Reference: 2-amino-6-nitro-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-nitro-phenol(603-87-2)
• EPA Substance Registry System: 2-amino-6-nitro-phenol(603-87-2)

Safety Data

• Hazardous Substances Data: 603-87-2(Hazardous Substances Data)

Usage

General Description

2-amino-6-nitro-phenol, also known as 2-Amino-6-nitrophenol or 6-nitro-o-aminophenol, is a chemical compound with the molecular formula C6H6N2O3. It is an aromatic compound with a yellow crystalline appearance and is slightly soluble in water. 2-amino-6-nitro-phenol is commonly used as an intermediate in the production of pharmaceuticals and dyes. It is also used in the manufacturing of hair dyes and pigments. 2-amino-6-nitro-phenol is known to be toxic if ingested or inhaled and can cause irritation to the skin and eyes. Due to its potentially harmful effects, proper precautions and handling procedures should be followed when working with 2-amino-6-nitro-phenol.

InChI:InChI=1/C6H6N2O3/c7-4-2-1-3-5(6(4)9)8(10)11/h1-3,9H,7H2

Upstream product

• 573-56-8 2,6-dinitrophenol 
• 74255-39-3 N-(2-hydroxy-3-nitrophenyl)acetamide 
• 95-55-6 2-amino-phenol 
• 7664-93-9 sulfuric acid 
• 860728-40-1 (4-amino-3-hydroxy-2-nitro-phenyl)-arsonic acid 
• 861528-05-4 (4-acetylamino-3-hydroxy-2-nitro-phenyl)-arsonic acid 
• 7647-01-0 hydrogenchloride 
• 860728-44-5 (4-glycoloylamino-3-hydroxy-2-nitro-phenyl)-arsonic acid 
• 614-80-2 2-(acetylamino)phenol 
• 606-21-3 1-chloro-2,6-dinitrobenzene 

Downstream Products

• 74255-39-3 N-(2-hydroxy-3-nitrophenyl)acetamide 
• 85126-68-7 2-chloro-N-(2-hydroxy-3-nitrophenyl)acetamide 
• 101494-76-2 7-nitrobenzo[d]oxazole-2(3H)-thione 
• 93021-17-1 (2-Hydroxy-3-nitro-phenylazo)-acetoacetanilid 
• 96-91-3 picramic acid 
• 99419-95-1 3-benzenesulfonyl-7-nitro-3H-benzoxazol-2-one 
• 106590-32-3 7-nitro-3-(toluene-4-sulfonyl)-3H-benzoxazol-2-one 
• 851886-82-3 1-(2-hydroxy-3-nitrophenyl)-3-mesitylthiourea 
• 915135-25-0 4-tert-butyl-N-(2-hydroxy-3-nitrophenyl)benzamide 
• 928196-54-7 2-hydroxy-3-nitro-benzenesulfonyl chloride 
• 915135-26-1 2-(4-tert-butylphenyl)-7-nitro-1,3-benzooxazole 
• 204771-74-4 2-ethyl-5-nitro-1,3-benzoxazole 
• 81282-60-2 7-aminobenzo[d]oxazol-2(3H)-one 
• 851886-83-4 N-mesityl-7-nitro-1,3-benzoxazol-2-amine 

Relevant articles and documents

Method for synthesizing benzoxazole compound by using nitration by-products of aromatic hydrocarbon and application of benzoxazole compound

The invention discloses a method for synthesizing a benzoxazole compound by using nitration by-products of aromatic hydrocarbon and application of the benzoxazole compound. The method comprises the main process: performing step-by-step crystallization on nitration products of a 2,4-dinitrochlorobenzene production enterprise so as to obtain 2,4-dinitrochlorobenzene, 2,6-dinitrochlorobenzene (I) anda small amount of residues, adopting the obtained 2,6-dinitrochlorobenzene (I) as the main starting material, and performing hydrolysis, selective catalytic hydrogenation reduction, cyclization, halogenation, carbon-carbon coupling and other processes so as to synthesize the benzoxazole compound, wherein the obtained compound can be used as a main raw material to synthesize a series of chemical intermediates with important application, and the chemical intermediates include o-aminophenol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol and hydrochloride of o-aminophenol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol. Through the method, the industrial by-products are converted into high value-added aromatic aminophenol products, industrial hazardous waste of the 2,4-dinitrochlorobenzene production enterprise is reduced, the scope of products of the enterprise is widened, and the economic benefits of enterprise are increased.

DISUBSTITUTED 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE COMPOUNDS FOR USE IN THE TREATMENT OF CHEMOKINE-MEDIATED PATHOLOGIES

Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds are disclosed that are represented by general formula (I). Also disclosed, are pharmaceutical compositions including these compounds and methods of using these compounds and compositions for the

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists based on a 4-piperazinylbenzimidazole template, we sought to investigate the properties of heterocyclic isosteres of the benzimidazole template. We report here the synthesis and biological activity of eight novel scaffolds, including imidazopyridines, benzothiazoles and benzoxazoles. The 2-(4-tert-butylphenyl)-8-(piperazin-1-yl)imidazo[1,2-a]pyridine ring system was shown to have nanomolar binding potency at the human and rat GnRH receptors as well as functional antagonism in vitro. Additional structure-activity relationships within this series are reported along with a pharmacokinetic comparison to the benzimidazole-based lead molecule.