60305-56-8 Usage
Description
(2S,3S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, commonly known as benzoyl ecgonine, is a chemical compound with the molecular formula C17H19NO4. It is a derivative of the natural alkaloid cocaine and is an ester of ecgonine and benzoic acid. Benzoyl ecgonine is a potent stimulant of the central nervous system and has a high potential for abuse.
Uses
Used in Forensic Toxicology and Drug Testing:
Benzoyl ecgonine is used as a reference standard in drug testing and forensic analysis. Its presence in biological samples is indicative of cocaine use, making it an important compound in identifying and confirming cocaine intake.
Used in Illicit Drug Detection:
Benzoyl ecgonine is typically found in illicit drugs such as cocaine. As a marker for cocaine intake, it plays a crucial role in the detection and analysis of illegal drug use and trafficking.
Used in Pharmaceutical Research:
As a derivative of cocaine, benzoyl ecgonine may also be used in pharmaceutical research to study the effects of stimulants on the central nervous system and to develop potential treatments for various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 60305-56-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,3,0 and 5 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 60305-56:
(7*6)+(6*0)+(5*3)+(4*0)+(3*5)+(2*5)+(1*6)=88
88 % 10 = 8
So 60305-56-8 is a valid CAS Registry Number.
60305-56-8Relevant articles and documents
Nonenzymatic hydrolysis of cocaine via intramolecular acid catalysis
Li, Pan,Zhao, Kang,Deng, Shixian,Landry, Donald W.
, p. 85 - 89 (2007/10/03)
The spontaneous hydrolysis of the methyl-ester group of cocaine (1) in vivo contributes to the metabolic clearance of the drug in man. Neighboring- group participation by the tropane N-atom of cocaine in this hydrolysis was suggested by the normal stability of the methyl-ester groups of pseudococaine and N-acylnorcocaine. For cocaine, the relative rate of methyl-ester to benzoyl-ester hydrolysis was ca. 10:1 at pH ≤ 7.4, and, although absolute rates increased with increasing pH, their ratio collapsed at pH > pK(a) (8.6). These data are consistent with intramolecular acid catalysis of alkaline hydrolysis of the cocaine methyl-ester group under physiologic conditions.
