60312-83-6

Basic information

• Product Name: 2-(3-BROMOPHENYL)-ACETAMIDE
• Synonyms: 3-BROMOPHENYLACETAMIDE;2-(3-BROMOPHENYL)-ACETAMIDE;Benzeneacetamide, 3-bromo-
• CAS NO: 60312-83-6
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 214.06
• Product Categories: Aryl;Organohalides
• Mol File: 60312-83-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 376.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.537±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.04±0.40(Predicted)
• CAS DataBase Reference: 2-(3-BROMOPHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-BROMOPHENYL)-ACETAMIDE(60312-83-6)
• EPA Substance Registry System: 2-(3-BROMOPHENYL)-ACETAMIDE(60312-83-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 60312-83-6(Hazardous Substances Data)

Usage

General Description

2-(3-Bromophenyl)-acetamide is a chemical compound with the molecular formula C8H8BrNO. It is an acetamide derivative with a bromine atom attached to the third position of a phenyl ring. 2-(3-BROMOPHENYL)-ACETAMIDE is commonly used in chemical research and pharmaceutical development due to its potential biological and medicinal properties. It has been reported to exhibit anti-inflammatory and analgesic effects, making it a promising candidate for the development of new drugs for pain management and inflammation-related conditions. Additionally, this compound may also be used as an intermediate in the synthesis of other organic compounds and pharmaceuticals. However, it is important to handle and use 2-(3-Bromophenyl)-acetamide with proper safety precautions, as it may pose health hazards if not handled properly.

Upstream product

• 31938-07-5 (3-bromophenyl)acetonitrile 
• 1878-67-7 3-Bromophenylacetic acid 
• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 98288-51-8 2-(3-bromophenyl)acetyl chloride 

Downstream Products

• 103-81-1 Benzeneacetamide 
• 843646-72-0 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 
• 60312-75-6 5-(3-bromo-phenyl)-1-methyl-1H-pyrimidin-4-one 
• 31938-07-5 (3-bromophenyl)acetonitrile 
• 1024584-25-5 C₂₆H₂₆BrN₃O₄ 
• 834861-78-8 2-(3-bromophenyl)ethanethioamide 
• 954241-25-9 C₁₃H₁₂BrNO₂S 

Relevant articles and documents

Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer. Due to its restricted expression pattern and dual enzymatic activities, FAP inhibition is investigated as a therapeutic option for several diseases. In the present study, we described the structure–activity relationship of several synthesized compounds against DPPIV and prolyl oligopeptidase (PREP). In particular, BR102910 (compound 24) showed nanomolar potency and high selectivity. Moreover, the in vivo FAP inhibition study of BR102910 (compound 24) using C57BL/6J mice demonstrated exceptional profiles and satisfactory FAP inhibition efficacy. Based on excellent in vitro and in vivo profiles, the potential of BR102910 (compound 24) as a lead candidate for the treatment of type 2 diabetes is considered.

Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration, and α-Deuterated Amide Formation via Metal Ligand Cooperation

A simple and efficient system for the hydration and α-deuteration of nitriles to form amides, α-deuterated nitriles, and α-deuterated amides catalyzed by a single pincer complex of the earth-abundant manganese capable of metal-ligand cooperation is reported. The reaction is selective and tolerates a wide range of functional groups, giving the corresponding amides in moderate to good yields. Changing the solvent from tert-butanol to toluene and using D2O results in formation of α-deuterated nitriles in high selectivity. Moreover, α-deuterated amides can be obtained in one step directly from nitriles and D2O in THF. Preliminary mechanistic studies suggest the transformations contributing toward activation of the nitriles via a metal-ligand cooperative pathway, generating the manganese ketimido and enamido pincer complexes as the key intermediates for further transformations.

Aryl-indolyl maleimides as inhibitors of CaMKIIδ. Part 1: SAR of the aryl region

A family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin dependant kinase. Inhibitory activities against the enzyme ranged from 34 nM to >20 μM and were dependant upon both the nature of the aryl group and the hydrogen bond donating potential of the maleimide ring. Key interactions with the kinase ATP site and hinge region were found to be consistent with homology modeling predictions.