60317-41-1

Basic information

• Product Name: ethyl (2Z)-2-(hydroxyimino)-3-oxo-3-phenylpropanoate
• Synonyms: 2-Hydroxyimino-3-oxo-3-phenyl-propionic acid ethyl ester
• CAS NO: 60317-41-1
• Molecular Formula: C₁₁H₁₁NO₄
• Molecular Weight: 221.2093
• Mol File: 60317-41-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 366.3°C at 760 mmHg
• Flash Point: 175.3°C
• Density: 1.2g/cm³
• Vapor Pressure: 5.19E-06mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: ethyl (2Z)-2-(hydroxyimino)-3-oxo-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2Z)-2-(hydroxyimino)-3-oxo-3-phenylpropanoate(60317-41-1)
• EPA Substance Registry System: ethyl (2Z)-2-(hydroxyimino)-3-oxo-3-phenylpropanoate(60317-41-1)

Safety Data

• Hazardous Substances Data: 60317-41-1(Hazardous Substances Data)

Upstream product

• 3885-45-8 ethyl 2,3-dioxo-3-phenylpropanoate 
• 109-95-5 ethyl nitrite 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 81471-31-0 3-oxo-3-phenyl-propionimidic acid ethyl ester; hydrochloride 
• 70582-90-0 2-Benzoylacetimidsaeure-ethylester 
• 98-86-2 acetophenone 
• 164661-67-0 ethyl (E)-2-hydroxyimino-3-oxo-3-phenylpropanoate 

Downstream Products

• 6966-30-9 ethyl 2-acetamido-3-oxo-3-phenylpropanoate 
• 122088-81-7 2-benzamide-3-oxo-3-phenylpropionic acid ethyl ester 
• 854461-63-5 optically inactive 2-hydroxy-3-nitro-1,4-diphenyl-butane-1,4-dione 
• 3306-06-7 (1RS,2SR)-2-amino-1-phenyl-propane-1,3-diol 
• 15917-28-9 (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid ethyl ester 
• 90560-40-0 phenyllactic acid 
• 3651-13-6 5-methyl-3-phenyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 89649-41-2 ethyl 3-phenylcyclopentapyrrole-2-carboxylate 
• 86398-23-4 3-nitroso-4-phenyl-5-cyanopyridine-2,6-diol 
• 119124-15-1 ethyl (Z)-2-methoxyimino-3-oxo-3-phenylpropanoate 
• 75-52-5 nitromethane 
• 64-17-5 ethanol 
• 94709-11-2 2,3,4-trimethoxybenzophenone 
• 88854-18-6 (2RS,3RS)-3-acetoxy-2-acetylamino-3-phenyl-propionic acid ethyl ester 

Relevant articles and documents

METHOD OF TREATING COCCIDIOIDES INFECTION

The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.

Rhodium-catalyzed asymmetric hydrogenation of tetrasubstituted β-acetoxy-α-enamido esters and efficient synthesis of droxidopa

A rhodium-catalyzed asymmetric hydrogenation of challenging tetrasubstituted β-acetoxy-α-enamido esters was developed, giving chiral β-acetoxy-α-amido esters in high yields with excellent enantioselectivities (up to >99% ee). The products could be easily transformed to β-hydroxy-α-amino acid derivatives which are valuable chiral building blocks and a novel route for the synthesis of droxidopa was also developed.

Tandem C-N Bond Formation through Condensation and Metal-Free N-Arylation: Protocol for Synthesizing Diverse Functionalized Quinoxalines

Diverse functionalized quinoxalines were synthesized in good yields from arylamines and readily available β-keto oximes through condensation and metal-free N-arylation. The reaction was compatible with various functional groups, such as halides, cyano, and esters. A mechanism was proposed based on the experimental results. These quinoxalines were easily obtained on a gram scale and converted to various useful scaffolds. Compound LASSBio-1022 was prepared in 83% yield in two steps.