6035-45-6 Usage
Description
Calcium folinate, also known as Leucovorin, is a synthetic form of folic acid and an intermediate product in the metabolism of folic acid. It is a mixture of diastereomers and appears as a yellowish-white to yellow powder. Calcium folinate plays a crucial role in the synthesis of nucleic acids and the metabolism of certain amino acids.
Uses
Used in Pharmaceutical Industry:
Calcium folinate is used as an antianemic agent for the treatment of anemia caused by folic acid deficiency. It helps in the production of red blood cells and supports the body's ability to fight anemia.
Used in Oncology:
Calcium folinate is used as a chemosensitizer in the treatment of certain types of cancer, particularly in combination with other chemotherapeutic agents like 5-FU (5-fluorouracil). It enhances the efficacy of these drugs by increasing their sensitivity to the cancer cells, leading to improved treatment outcomes.
Used in Drug Metabolism:
Calcium folinate is used as a supplement in the treatment of megaloblastic anemia caused by inborn errors of folic acid metabolism. It aids in the proper functioning of the body's metabolic processes and supports overall health.
Used in Research and Development:
Calcium folinate is also used in research and development for studying the role of folic acid in various biological processes and its potential applications in the development of new drugs and therapies.
Biological Activity
human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (mtx)-induced growth suppression. over a 72h continuous exposure leucovorin provided better protection to the cell lines laz-007 and raji than to the cell line
Check Digit Verification of cas no
The CAS Registry Mumber 6035-45-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,3 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6035-45:
(6*6)+(5*0)+(4*3)+(3*5)+(2*4)+(1*5)=76
76 % 10 = 6
So 6035-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0....../s1
6035-45-6Relevant articles and documents
Process for the preparation and separation of diastereomeric salts of folinic acid
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, (2008/06/13)
A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine and the subsequent separation of the diasteromeric salts.
