6036-14-2

Basic information

• Product Name: (2-naphthyloxy)acetic acid ethyl ester
• Synonyms: (2-naphthyloxy)acetic acid ethyl ester
• CAS NO: 6036-14-2
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.26
• Mol File: 6036-14-2.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 353.4°C at 760 mmHg
• Flash Point: 147.1°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 3.61E-05mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: (2-naphthyloxy)acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-naphthyloxy)acetic acid ethyl ester(6036-14-2)
• EPA Substance Registry System: (2-naphthyloxy)acetic acid ethyl ester(6036-14-2)

Safety Data

• Hazardous Substances Data: 6036-14-2(Hazardous Substances Data)

Usage

Description

(2-Naphthyloxy)acetic acid ethyl ester, also known as 2-(naphthalen-2-yloxy)acetic acid ethyl ester, is an ethyl ester derivative of (2-naphthyloxy)acetic acid. It is a chemical compound with potential biological and pharmacological activities, including anti-inflammatory and anti-cancer properties. It also has an impact on the central nervous system, making it a promising candidate for pharmaceutical drug development.

Uses

Used in Pharmaceutical Industry:
(2-Naphthyloxy)acetic acid ethyl ester is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its anti-inflammatory and anti-cancer properties make it a valuable component in the development of new drugs for treating inflammation and cancer.
Used in Agrochemical Industry:
(2-Naphthyloxy)acetic acid ethyl ester is also used as a chemical intermediate in the synthesis of agrochemicals. Its potential applications in this industry include the development of new pesticides or herbicides to improve crop protection and yield.
Used in Organic Compounds Synthesis:
(2-Naphthyloxy)acetic acid ethyl ester is used as a chemical intermediate in the synthesis of various organic compounds. Its diverse range of properties and potential benefits make it a valuable component in the development of new organic compounds for various industrial applications.
Used in Central Nervous System Research:
Due to its impact on the central nervous system, (2-Naphthyloxy)acetic acid ethyl ester is used in research to explore its potential as a pharmaceutical drug for the treatment of neurological disorders or conditions affecting the central nervous system.

InChI:InChI=1/C14H14O3/c1-2-16-14(15)10-17-13-8-7-11-5-3-4-6-12(11)9-13/h3-9H,2,10H2,1H3

Upstream product

• 120-23-0 (2-naphthoyl)oxyacetic acid 
• 64-17-5 ethanol 
• 875-83-2 sodium 2-naphtholate 
• 105-39-5 chloroacetic acid ethyl ester 
• 135-19-3 β-naphthol 
• 36294-21-0 potassium 2-naphthoxide 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 35368-77-5 2-naphthalen-2-yloxy-acetamide 
• 120-23-0 (2-naphthoyl)oxyacetic acid 
• 36304-47-9 1-(2-naphthyloxyacetyl)hydrazine 
• 905261-90-7 C₁₉H₁₆ClN₃O₂S 
• 136414-04-5 5-(naphthalen-2-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 51510-43-1 1-([2]-naphthyloxy-acetyl)-4-phenyl thiosemicarbazide 
• 1285706-00-4 benzaldehyde 2-naphthyloxyacetamidoacetohydrazone 
• 1285706-01-5 acetophenone 2-naphthyloxyacetamidoacetohydrazone 
• 1285706-04-8 4-bromobenzaldehyde 2-naphthyloxyacetamidoacetohydrazone 
• 1285706-02-6 4-methylbenzaldehyde 2-naphthyloxyacetamidoacetohydrazone 
• 1285706-03-7 4-methoxybenzaldehyde 2-naphthyloxyacetamidoacetohydrazone 

Relevant articles and documents

Design, synthesis and in vitro antibacterial evaluation of naphthalen-2-yloxy based oxadiazole-2-thione derivatives

A series of novel Mannich bases 5-(naphthalen-2-yloxymethyl)-3-(substituted)aminomethyl-3H-[1,3,4]oxadiazole-2-thiones (5a-h) were synthesized by aminomethylation of substituted-1,3,4-oxadiazole-2(3H)-thione by equimolar concentration of primary or second

Regioselective synthesis of spiro naphthofuranone-pyrazoline via a [3+2] cycloaddition of benzoaurones with nitrile imines

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Synthesis and computer-aided analysis of the role of linker for novel ligands of the 5-HT6 serotonin receptor among substituted 1,3,5-triazinylpiperazines

A series of 2-amino-4-(4-methylpiperazin-1-yl)-1,3,5-triazines was designed based on previously published 2-amino-4-benzyl-(4-methylpiperazin-1-yl)-1,3,5-triazines in order to evaluate the role of a linker between the triazine moiety and an aromatic substituent for the human serotonin 5-HT6 receptor affinity. As new linkers two carbon atoms (ethyl or ethenyl) or an oxyalkyl chain (methoxy, 2-ethoxy, 2-propoxy) were introduced. Affinities of the compounds for the 5-HT6R as the main target, and for the 5-HT1AR, 5-HT7R and D2R as competitive ones, were determined in the radioligand binding assays. Docking to the 5-HT6R homology model was performed to support SAR analysis. Results showed that the branching of the methoxyl linker increased affinity for the human 5-HT6R whereas an unsaturated bond within the linker dramatically reduced desirable activity. Both experimental and theoretical studies confirmed the previously postulated beneficial role of the aromatic size for interaction with the 5-HT6R. Thus, the largest naphthyl moiety yielded the highest activity. In particular, 4-(4-methylpiperazin-1-yl)-6-(1-(naphthalen-1-yloxy)ethyl)-1,3,5-triazin-2-amine (24), the most potent 5-HT6R agent found (Ki = 23 nM), can be a new lead structure for further search and development.