60366-01-0

Basic information

• Product Name: 1-Butanone, 2-methyl-1,2-diphenyl-, (R)-
• CAS NO: 60366-01-0
• Molecular Formula: C17H18O
• Molecular Weight: 238.329
• Mol File: 60366-01-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Butanone, 2-methyl-1,2-diphenyl-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 2-methyl-1,2-diphenyl-, (R)-(60366-01-0)
• EPA Substance Registry System: 1-Butanone, 2-methyl-1,2-diphenyl-, (R)-(60366-01-0)

Safety Data

• Hazardous Substances Data: 60366-01-0(Hazardous Substances Data)

Upstream product

• 133038-72-9 (R)-N,N-diisopropyl O-(1-phenyl)ethylcarbamate 
• 1201898-74-9 (S)-4,4,5,5-tetramethyl-2-(2-phenylbutan-2-yl)-1,3,2-dioxaborolane 
• 1413934-94-7 (R)-2-methyl-1,2-diphenylbut-3-en-1-one 
• 100-52-7 benzaldehyde 
• 99808-99-8 (R,S)-α-[(tert-butyldimethylsilyl)oxy]-α-(phenyl)acetonitrile 
• 1190868-78-0 (2R)-2-methyl-1,2-diphenylbutan-1-ol 
• 2674-04-6 diphenyl cadmium 
• 157750-19-1 (-)-(2R)-2-Methyl-2-phenylbutanoyl chloride 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 29555-78-0 (S)-2-methyl-1,2-diphenyl-butane 
• 94860-00-1 (1R,2R)-2-methyl-1,2-diphenyl-butan-1-ol 
• 94860-00-1 (1S,2R)-2-methyl-1,2-diphenyl-butan-1-ol 
• 101787-48-8 (2Ξ,3S)-3-methyl-2,3-diphenyl-pentan-2-ol 
• 94860-00-1 (1R,2S)-2-methyl-1,2-diphenyl-butan-1-ol 
• 94860-00-1 (1S,2S)-2-methyl-1,2-diphenyl-butan-1-ol 

Relevant articles and documents

Tertiary alkylations of aldehydes, ketones or imines using benzylic organoboronates and a base catalyst

The KHMDS-catalyzed tertiary alkylation of aldehydes, ketones or imines using tertiary benzylic organoboronates is reported. This protocol permitted the use of tertiary benzylic alkylboronates as the tertiary alkyl anion for construction of highly congested contiguous sp3 carbon centers. The mild and transition-metal-free reaction conditions are attractive features of the protocol.

Rhodium-catalyzed allylic substitution with an acyl anion equivalent: Stereospecific construction of acyclic quaternary carbon stereogenic centers

A highly regio- and stereospecific rhodium-catalyzed allylic alkylation of tertiary allylic alcohol derivatives with a cyanohydrin pronucleophile is described. This direct and operationally simple protocol provides a fundamentally novel approach toward the synthesis of α-quaternary substituted ketones and circumvents many of the inherent problems associated with conventional enolate alkylation reactions. The stereospecific variant of this reaction provides the enantiomerically enriched α-quaternary substituted allylic aryl ketone, which is a particularly challenging intermediate for more conventional enolate-based strategies.