60388-53-6

Basic information

• Product Name: DL-Amethopterin hydrate
• Synonyms: DL-4-Amino-N10-methylpteroylglutamic acid; (plus-minus)-amethopterin
• CAS NO: 60388-53-6
• Molecular Formula: C₂₀H₂₂N₈O₅
• Molecular Weight: 454.445
• EINECS: 262-213-7
• Product Categories: RHEUMATREX
• Mol File: 60388-53-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 195℃
• Density: 1.536±0.06 g/cm3(Predicted)
• Storage Temp.: ?20°C
• Solubility: H2O: Add a minimal amount of 0.1燦 NaOH to solubilize, then dilute in neutral buffer or saline. Diluted stock is stable for 1爓eek refrigerated and for 1爉onth frozen at?#8722;20?#x00b0;C.insoluble
• PKA: 3.47±0.10(Predicted)
• CAS DataBase Reference: DL-Amethopterin hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: DL-Amethopterin hydrate(60388-53-6)
• EPA Substance Registry System: DL-Amethopterin hydrate(60388-53-6)

Safety Data

• Hazard Codes: T:Toxic
• Statements: R46:May cause heritable genetic damages.; R61:May cause harm to the unborn child.
• Safety Statements: S45:In case of accident of if you feel unwell, seek medical advice immediately (show the label where possible).; S53:Avoi
• RIDADR: UN 1544 6.1/PG 2
• WGK Germany: 3
• RTECS: MA1224100
• Hazardous Substances Data: 60388-53-6(Hazardous Substances Data)

Usage

Description

DL-Amethopterin hydrate, also known as Racemic Methotrexate, is a folic acid antagonist and an anticancer agent. It is a synthetic compound that exhibits antineoplastic and antirheumatic properties, making it a valuable pharmaceutical candidate for various applications.
Source:
DL-Amethopterin hydrate is a synthetic compound derived from the chemical synthesis process.
Production Methods:
The production of DL-Amethopterin hydrate involves chemical synthesis methods, which may vary depending on the specific process used.

Uses

Used in Oncology:
DL-Amethopterin hydrate is used as an antineoplastic agent for the treatment of various types of cancer. It works by inhibiting the activity of dihydrofolate reductase, an enzyme involved in the synthesis of DNA and RNA, thereby preventing the growth and proliferation of cancer cells.
Used in Rheumatology:
DL-Amethopterin hydrate is used as an antirheumatic agent for the treatment of various inflammatory and autoimmune conditions, such as rheumatoid arthritis, psoriasis, and lupus. It helps to reduce inflammation and alleviate symptoms associated with these conditions.
Used in Pharmaceutical Industry:
DL-Amethopterin hydrate is used as a folic acid antagonist in the development of pharmaceutical drugs for the treatment of cancer and autoimmune diseases. Its unique properties make it a valuable component in the formulation of medications that target specific cellular processes and pathways.

Downstream Products

• 34378-65-9 methotrexate dimethyl ester 
• 59-05-2 (+)-amethopterin 
• 5939-37-7 (+/-)-7-hydroxymethotrexate 
• 112163-39-0 7-cyanomethotrexate dimethyl ester 
• 7413-34-5 methotrexate disodium salt 

Relevant articles and documents

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Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid

The synthesis and some biological testing results are reported for dichlorohomofolic acid (2a) and 3 methotrexate (MTX) analogs in which the L glutamic acid moiety was replaced by D glutamic acid, glutaric acid, and L lysine to give 4b, 4c, and 4d, respec