604-33-1 Usage
Description
Cholesteryl linoleate, also known as the (9Z,12Z)-stereoisomer of cholesteryl octadeca-9,12-dienoate, is a naturally occurring compound derived from the esterification of cholesteryl and linoleic acid. It is a type of cholesterol ester that plays a role in various biological processes and has been utilized in different applications due to its unique properties.
Uses
Used in Pharmaceutical and Biomedical Research:
Cholesteryl linoleate is used as a research tool for studying the cholesterol to phospholipid ratio in red blood cell membranes. This application helps in understanding the structural and functional aspects of cell membranes, which is crucial for various biomedical and pharmaceutical research.
Used in Analytical Chemistry:
Cholesteryl linoleate serves as a high-performance liquid chromatography (HPLC) standard in the analysis of rat liver lipoproteins. This application is essential for accurate quantification and identification of lipoproteins, which are vital for understanding lipid metabolism and related health conditions.
Used in the Preparation of Dispersions:
Cholesteryl linoleate is used in the co-sonication with cholesterol to prepare dispersions for studying the properties of red blood cell membranes. This application aids in the development of novel drug delivery systems and the investigation of membrane-related phenomena.
Biochem/physiol Actions
Cholesteryl linoleate is a major cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters. The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.
Check Digit Verification of cas no
The CAS Registry Mumber 604-33-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 604-33:
(5*6)+(4*0)+(3*4)+(2*3)+(1*3)=51
51 % 10 = 1
So 604-33-1 is a valid CAS Registry Number.
InChI:InChI=1/C46H78O2/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-26-43(47)48-39-30-33-44(5)38(35-39)29-32-46(7)41-28-27-40(37(4)25-23-24-36(2)3)45(41,6)34-31-42(44)46/h12-13,15-16,29,36-37,39-42H,8-11,14,17-28,30-35H2,1-7H3/b13-12-,16-15-/t37-,39+,40-,41-,42-,44+,45-,46+/m1/s1
604-33-1Relevant articles and documents
Enzymatic synthesis of steryl esters of polyunsaturated fatty acids
Shimada, Yuji,Hirota, Yoshinori,Baba, Takashi,Sugihara, Akio,Moriyama, Shigeru,Tominaga, Yoshio,Terai, Tadamasa
, p. 713 - 716 (1999)
Steryl esters of long-chain fatty acids have water-holding properties, and polyunsaturated fatty acids (PUFA) have various physiological functions. Because steryl ester of PUFA can be expected to have both features, we attempted to synthesize steryl esters of PUFA by enzymatic methods. Among lipases used, Pseudomonas lipase was the most effective for the synthesis of cholesteryl docosahexaenoate. When a mixture of cholesterol/docosahexaenoic acid (3:1, mol/mol), 30% water, and 3000 units/g of lipase was stirred at 40 °C for 24 h, the esterification extent attained 89.5%. Under the same reaction conditions, cholesterol, cholestanol, and sitosterol were also esterified efficiently with docosahexaenoic, eicosapentaenoic, arachidonic, and γ-linolenic acids.
ESTERS OF DCPLA AND METHODS OF TREATMENT USING THE SAME
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Paragraph 0112, (2013/05/23)
The present disclosure relates to esters of 8-[2-(2-pentyl- cyclopropylmethyl)cyclopropyl]-octanoic acid ("DCPLA"). The disclosure further relates to compositions, kits, and methods for treatment using the esters.
