604-51-3 Usage
Description
Deptropine, also known as 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl ether of tropine, is an azabicycloalkane derivative with potential applications in various fields. It is characterized by its unique chemical structure, which allows it to interact with specific biological targets and exhibit a range of pharmacological effects.
Uses
Used in Pharmaceutical Industry:
Deptropine is used as an antihistaminic agent for its ability to counteract the effects of histamine, a compound involved in various allergic and inflammatory responses. By blocking histamine receptors, deptropine can help alleviate symptoms associated with allergies, such as itching, redness, and swelling.
Used in Research and Development:
In addition to its pharmaceutical applications, deptropine may also be utilized in research and development settings. Its unique chemical structure and biological activity make it a valuable tool for studying the mechanisms of histamine action and developing new therapeutic strategies for allergy and inflammation-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 604-51-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 604-51:
(5*6)+(4*0)+(3*4)+(2*5)+(1*1)=53
53 % 10 = 3
So 604-51-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H27NO/c1-24-18-12-13-19(24)15-20(14-18)25-23-21-8-4-2-6-16(21)10-11-17-7-3-5-9-22(17)23/h2-9,18-20,23H,10-15H2,1H3
604-51-3Relevant articles and documents
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein
Edink, Ewald,Akdemir, Atilla,Jansen, Chimed,Elk, René Van,Zuiderveld, Obbe,De Kanter, Frans J.J.,Van Muijlwijk-Koezen, Jacqueline E.,Smit, August B.,Leurs, Rob,De Esch, Iwan J.P.
supporting information; experimental part, p. 1448 - 1454 (2012/04/04)
Using structure-based optimization procedures on in silico hits, dibenzosuberyl- and benzoate substituted tropines were designed as ligands for acetylcholine-binding protein (AChBP). This protein is a homolog to the ligand binding domain of the nicotinic acetylcholine receptor (nAChR). Distinct SAR is observed between two AChBP species variants and between the α7 and α4β2 nAChR subtype. The AChBP species differences are indicative of a difference in accessibility of a ligand-inducible subpocket. Hereby, we have identified a region that can be scrutinized to achieve selectivity for nicotinic receptor subtypes.
