60426-97-3

Basic information

• Product Name: Propanoic acid, 2-(acetyloxy)-, methyl ester, (R)-
• CAS NO: 60426-97-3
• Molecular Formula: C6H10O4
• Molecular Weight: 146.143
• Mol File: 60426-97-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-(acetyloxy)-, methyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-(acetyloxy)-, methyl ester, (R)-(60426-97-3)
• EPA Substance Registry System: Propanoic acid, 2-(acetyloxy)-, methyl ester, (R)-(60426-97-3)

Safety Data

• Hazardous Substances Data: 60426-97-3(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 547-64-8 methyl lactate 
• 77287-29-7 methyl (2R)-2-chloropropanoate 
• 143314-17-4 1-ethyl-3-methylimidazolium acetate 
• 27871-49-4 (S)-Methyl lactate 
• 876-27-7 4-chlorophenyl acetate 
• 686-46-4 methyl 2-acetoxyacrylate 

Relevant articles and documents

Process for preparing esters and organic halides

A process for preparing esters and organic halides, which comprises reacting - a salt having a melting point of less than 100°C (at 1 bar) and of the formula ???????? (K+)n X (COO-)n, in which K+ is an organic cation, X (COO-)n is an organic anion having an n-valent organic group X which is substituted by n carboxylate groups COO-, and n is 1, 2 or 3, - with an organic halogen compound (Hal)mY, in which Hal is a halogen atom, Y is an m-valent organic group, and m is 1, 2 or 3, to give an ester and a halide K+ Hal-.

Efficient and highly enantioselective Rh-catalyzed hydrogenations of unsaturated lactate precursors with chiral bisphospholanes as ligands

The current invention relates to an asymmetric hydrogenation process of prochiral α-acetoxy acrylic acid esters for the synthesis of enantiopure lactic acid esters by the use of Rh-catalyzed bisphospholane ligands in a unit using an autoclave, and a distillation process. In a first process step α-acetoxy acrylic acid esters (1) and Rh-catalyzed bisphospholane ligands are dissolved in a solvent as substrate solution, in a second process step the substrate solution is added to an evacuated autoclave, in a third process step H2 is fed into the autoclave, in a fourth process step the asymmetric hydrogenation reaction is carried out under H2-pressure, and in a fifth process step the reaction product composed of solvent, lactic acid esters (2), remaining α-acetoxy acrylic acid esters (1) and Rh-catalyzed bisphospholane ligands is transferred into a distillation unit, is being distilled and enantiopure lactic acid esters (2) are separated from solvent, α-acetoxy acrylic acid esters (1) and Rh-catalyzed bisphospholane ligands. In this process propylene carbonate is used as solvent in the first process step, and the distillation is performed in a Spaltrohrkolonne in the fifth process step.

New ferrocenyl ligands with broad applications in asymmetric catalysis

A new synthetic approach allows the synthesis of taniaphos- analogous ligands 2 with inverted α configuration (Sp, αS). This new class of ferrocenyl ligands displays excellent enantioselectivity and enhanced reactivity in several types of asymmetric hydrogenation reactions (e.g. 1→).