60470-15-7

Basic information

• Product Name: benzyl tert-butyl carbonate
• Synonyms: benzyl tert-butyl carbonate
• CAS NO: 60470-15-7
• Molecular Weight: 208.257
• Mol File: 60470-15-7.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: benzyl tert-butyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl tert-butyl carbonate(60470-15-7)
• EPA Substance Registry System: benzyl tert-butyl carbonate(60470-15-7)

Safety Data

• Hazardous Substances Data: 60470-15-7(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100-51-6 benzyl alcohol 
• 507-19-7 t-butyl bromide 
• 124-38-9 carbon dioxide 
• 445-29-4 o-fluoro-benzoic acid 
• 121-92-6 3-nitrobenzoic acid 

Downstream Products

• 870-46-2 t-butoxycarbonylhydrazine 
• 35863-45-7 2,2-dimethyl-3-phenylpropanenitrile 
• 1320337-31-2 benzyl 4,6-di-O-acetyl-2,3-dideoxy-3-ethylthio-α-D-arabino-hexopyranoside 
• 1037210-08-4 bis-CBz-cyclopamine 
• 34577-40-7 3-benzyl-3-pentanol 
• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 705-58-8 3-methyl-1-phenyl-2-butanol 
• 105735-62-4 3,3-dimethyl-1-phenyl-2-butanol 
• 1944-01-0 1-benzylcyclohexan-1-ol 

Relevant articles and documents

Nickel-Catalyzed Benzylic Substitution of Benzyl Esters with Malonates as a Soft Carbon Nucleophile

The nickel-catalyzed benzylic substitution of benzyl alcohol derivatives with a soft carbon nucleophile is extremely rare compared to that with a hard carbon nucleophile. We have achieved the nickel-catalyzed benzylic substitution of benzyl esters with malonates as a soft carbon nucleophile. Primary and secondary benzyl 2,3,4,5,6-pentafluorobenzoates as well as a wide variety of malonate derivatives were well tolerated in the nickel-catalyzed reaction, providing the corresponding alkylation products in 46-86% yields (34 examples). Additionally, we propose a possible reaction mechanism that would undergo via the ??1- A nd ??3-benzylnickel intermediates.

PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).

A new, efficient, and catalyst-free microwave-assisted approach for formation of O-tert-butoxy carbonates

A new simple, efficient, greener, and catalyst-free chemoselective protocol for the O-tert-butoxycarbonylation of various structurally diverse hydroxy compounds was carried out with (Boc)2O under microwave radiation. The corresponding O-tertbutoxy carbonates were obtained in good to excellent yields in a short reaction time without any side reactions.