604756-32-3

Basic information

• Product Name: ETHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBOXYLATE
• Synonyms: ETHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBOXYLATE;Ethyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate;3-keto-4H-1,4-benzoxazine-6-carboxylic acid ethyl ester;3-oxo-4H-1,4-benzoxazine-6-carboxylic acid ethyl ester;ethyl 3-oxo-4H-1,4-benzoxazine-6-carboxylate
• CAS NO: 604756-32-3
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 221.211
• Mol File: 604756-32-3.mol
• Article Data: 22

Chemical Properties

• Melting Point: 130-132 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 417.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.269±0.06 g/cm3(Predicted)
• PKA: 12.09±0.20(Predicted)
• CAS DataBase Reference: ETHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBOXYLATE(604756-32-3)
• EPA Substance Registry System: ETHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBOXYLATE(604756-32-3)

Safety Data

• Hazardous Substances Data: 604756-32-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 134997-87-8 6-Carboxy-2,3-dihydro-3-oxo-4H-1,4-benzoxazine 
• 177199-66-5 3-amino-4-carbamoylmethoxy-benzoic acid methyl ester 
• 82525-66-4 3-(2-chloro-acetylamino)-4-hydroxy-benzoic acid methyl ester 
• 83785-14-2 methyl 4-(2-methoxy-2-oxo-ethoxy)-3-nitrobenzoate 
• 177199-67-6 4-carbamoylmethoxy-3-nitro-benzoic acid methyl ester 
• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 99-42-3 methyl (4-hydroxy-3-nitro)benzoate 
• 616-82-0 3-nitro-4-hydroxybenzoic acid 
• 19360-67-9 4-carboxymethoxy-benzoic acid 
• 35005-30-2 methyl 4-(2-methoxy-2-oxoethoxyl)benzoate 
• 25253-99-0 4-carboxymethoxy-3-nitro-benzoic acid 
• 79-04-9 chloroacetyl chloride 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 134997-87-8 6-Carboxy-2,3-dihydro-3-oxo-4H-1,4-benzoxazine 
• 758684-29-6 methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylate 
• 615568-17-7 6-hydroxymethyl-4H-benzo[1,4]oxazin-3-one 
• 915160-96-2 (3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-methanol 

Relevant articles and documents

Novel morpholin-3-one fused quinazoline derivatives as EGFR tyrosine kinase inhibitors

A series of novel morpholin-3-one-fused quinazoline derivatives were designed, synthesized and evaluated as EGFR tyrosine kinase inhibitors. Nineteen compounds showed significant inhibitory activities against EGFRwtkinase (IC50?wt(IC50?=?53.1?nM). Compound a7 and a8 showed excellent inhibitory activities against mutant EGFRT790M/L858Rand strong antiproliferative activity against H358 and A549 cell lines. Finally, molecular docking studies were performed to predict the possible binding mode of the target compounds. It is believed that this work would be very useful for designing a new series of tyrosine kinase inhibitors targeting EGFR.

QUINAZOLINE HETEROCYCLIC COMPOUND AS EGFR KINASE INHIBITOR AND PREPARATION AND APPLICATION THEREOF

The present invention relates to an N-substituted-phenyl-5-substituted-alkoxy-2,3-dihydro-[1,4]dioxane[2,3-f]quinazolin-10-amine (I) or 4-substituted-arylamino-6-substituted-alkyl-6H-[1,4]oxazino[3,2-g]quinazoline-7(8H)-one (II) type compounds, a preparation method thereof and an application thereof as an inhibitor for epidermal growth factor receptor (EGFR) (comprising some mutant forms of EGFR) to treat cancer. These compounds and salts thereof can be used to treat or prevent various cancer diseases.

A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid

A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.