6049-56-5

Basic information

• Product Name: N-Phenyl-β-phenyl-β-alanine
• Synonyms: N-Phenyl-β-phenyl-β-alanine
• CAS NO: 6049-56-5
• Molecular Weight: 241.29
• Mol File: 6049-56-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-Phenyl-β-phenyl-β-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Phenyl-β-phenyl-β-alanine(6049-56-5)
• EPA Substance Registry System: N-Phenyl-β-phenyl-β-alanine(6049-56-5)

Safety Data

• Hazardous Substances Data: 6049-56-5(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 142-04-1 aniline hydrochloride 
• 185106-85-8 N-[(Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-phenylethenyl]aniline 
• 742-43-8 1,3-diphenyl-3-(N-phenylamino)propanone 
• 95003-25-1 C₂₁H₂₀N₂O 
• 6846-55-5 ethyl 3-anilino-3-phenylpropanoate 
• 13474-22-1 1,4-diphenyl-azetidin-2-one 
• 201024-81-9 C,N-diphenylnitrone 
• 15463-91-9 3-bromo-3-phenylpropionic acid 
• 62-53-3 aniline 

Downstream Products

• 179173-50-3 1-[[1-[3-Phenyl-3-(phenylamino)propionyl]-4-piperidyl]methyl]-1H-2-methylimidazo[4,5-c]pyridine 
• 15148-17-1 3-phenyl-3-(phenylamino)propan-1-ol 
• 13474-22-1 1,4-diphenyl-azetidin-2-one 

Relevant articles and documents

Natural phosphate modified with lithium nitrate: A new efficient catalyst for the construction of carbon-carbon, carbon-sulfur, and carbon-nitrogen bonds

The addition of small amounts of lithium nitrate to natural phosphate followed by calcination gives a new catalyst Li/NP (weight ratio LiNO3/NP = 1/15). This material showed catalytic activity in the Michael addition of amines, mercaptans, and active methylene compounds to chalcone derivatives with high yields under mild reaction conditions. Li/NP is used as the catalyst for a facile synthesis of -amino acids, -sulfur acids, and 4 H-chromenes under heterogeneous conditions. The usual, undesirable byproducts from the Michael condensation such as 1,2-addition, bis-addition, and polymerization compounds are not observed with this method. The work-up procedure is simplified by simple filtration with the use of Li/NP.

A new and mild synthesis of β-amino acids from masked β-enamino acid derivatives

A new method of synthesis of racemic β-amino acids 6 by reduction of masked N-substituted and N-unsubstituted β-enamino acid derivatives 4 via C- protected β-amino acids 5 is described. The process occurs with high yields, total chemoselectivity and moderate diastereoselectivity. Readily available starting materials, inexpensive reagents and mild conditions are used to furnish derivatives 5 and 6.

(2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists

The present invention relates to new (2-alkyl-3-pyridyl) methylpiperazine derivatives of general formula I: wherein R1, R2 and Z are as defined in Claim 1. The invention also relates to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent, orally active PAF antagonists and, consequently, they are useful in the treatment of the diseases in which this substance is involved.