60521-25-7

Basic information

• Product Name: (2E)-3-(3,4-dimethylphenyl)acrylic acid
• Synonyms: (2E)-3-(3,4-dimethylphenyl)acrylic acid;3-(3,4-Dimethylphenyl)acrylic acid;3-(3,4-Dimethylphenyl)-2-propenoic acid
• CAS NO: 60521-25-7
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21178
• Mol File: 60521-25-7.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2E)-3-(3,4-dimethylphenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(3,4-dimethylphenyl)acrylic acid(60521-25-7)
• EPA Substance Registry System: (2E)-3-(3,4-dimethylphenyl)acrylic acid(60521-25-7)

Safety Data

• Hazardous Substances Data: 60521-25-7(Hazardous Substances Data)

Usage

Description

(2E)-3-(3,4-dimethylphenyl)acrylic acid, also known as 3-(3,4-dimethylphenyl)-2-propenoic acid, is a type of unsaturated carboxylic acid with the molecular formula C11H12O2. It features a double bond in the 2E position and a 3,4-dimethylphenyl group attached to the acrylic acid backbone.

Uses

Used in Pharmaceutical Industry:
(2E)-3-(3,4-dimethylphenyl)acrylic acid is used as a building block in the synthesis of pharmaceuticals and other organic compounds. Its unique structure and properties make it a valuable component in the development of new drugs and therapeutic agents.
Used in Research and Development:
(2E)-3-(3,4-dimethylphenyl)acrylic acid is employed in research and development to investigate its potential biological and pharmacological properties. This allows scientists to explore its applications in various fields, such as medicine, agriculture, and materials science.

Upstream product

• 5973-71-7 3,4-dimethylbenzaldehyde 
• 141-82-2 malonic acid 
• 22884-95-3 3,4-dimethylbenzonitrile 
• 6966-10-5 3,4-dimethylbenzyl alcohol 
• 38404-42-1 methyl 3,4-dimethylbenzoate 
• 619-04-5 3,4-dimethylbenzoic acid 
• 95-47-6 o-xylene 
• 79-10-7 acrylic acid 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 1018448-69-5 (E)-methyl 3-(3,4-dimethylphenyl)acrylate 
• 21900-23-2 3,4-dimethylbenzoyl chloride 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 25173-76-6 3-(3,4-dimethylphenyl)propionic acid 
• 16440-97-4 5,6-Dimethylindan-1-one 
• 16440-98-5 6,7-dimethyl-2,3-dihydro-1H-inden-1-one 
• 112631-49-9 3-(2-bromo-4,5-dimethylphenyl)propionic acid 
• 26801-37-6 3-(3,4-dimethylphenyl)propionyl chloride 
• 1075-22-5 5,6-dimethylindane 
• 1310329-66-8 (E)-(3,4-dimethyl)styryl diphenylphosphine oxide 
• 1559077-92-7 (E)-1,2-dimethyl-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene 
• 28075-29-8 N-methyl-3,3-diphenylpropylamine 
• 348607-76-1 3,3-diphenylpropanoic acid N-methylamide 
• 1000307-29-8 (E)-1-(3,4-dimethyl)-4-(2-nitrovinyl)benzene 

Relevant articles and documents

Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites

The Fujiwara-Moritani reaction has had a profound contribution in the emergence of contemporary C-H activation protocols. Despite the applicability of the traditional approach in different fields, the associated reactivity and regioselectivity issues had

Kukoamine B derivative compound, preparation method and applications thereof

The invention relates to a kukoamine B derivative compound, a preparation method and applications thereof, and belongs to the field of biological medicines, wherein the structural general formula is represented by a formula (I) or a formula (II), R1, R2, R3 and R4 are respectively and independently any one selected from -OH, -OCH3, -CH3 and -NH2, R5, R6 and R7 are respectively and independently any one selected from H, -CH3, -CH2NH2, -CH2CH2NH2 and -CH2CH2CH2NH2, and m is a natural number. According to the invention, a series of kukoamine B derivative compounds are synthesized and prepared, and are used as PD-1/PD-L1 axis inhibitors for the first time, and anti-tumor effect is realized by inhibiting PD-1/PD-L1 binding so as to provide new drug selection for the prevention and/or treatmentof tumors.

Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides

Abstract: A series of amides based on (2S)-cyanopyrrolidine and α, β-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in the oral glucose tolerance test in mice. Amides based on (E)-3-phenylprop-2-enoic and (E)-3-(4-methoxyphenyl)prop-2-enoic acids and (2S)-cyanopyrrolidine have been shown to significantly reduce blood glucose levels in mice. The observed hypoglycemic effect at a dose of 10 mg/kg is comparable to the effect of hypoglycemic drug vildagliptin.