60536-17-6Relevant articles and documents
Microwave-promoted N-alkylation of acridones without solvent
Wang, Cunde,Hang, Tianlong,Zhang, Hui
, p. 451 - 456 (2003)
N-Alkylacridones (3) were effectively synthesized in few minutes by reaction of acridone and alkyl halides with NaOH/K2CO3 absorbed on Al2O3 in the presence of TBAB under microwave irradiation without solvent.
Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents
Chimnoi, Nitirat,Eurtivong, Chatchakorn,Jumpathong, Watthanachai,Khunnawutmanotham, Nisachon,Techasakul, Supanna
, p. 410 - 425 (2020/03/23)
Acridine-based compounds possess anticancer activities by intercalating to DNA. Although they have chemotherapeutic potential, acridine-based compounds are not used to treat cancer. In this study, 2,N10-acridone derivatives are designed and synthesized based on acridone, a ketone derivative of acridine. Herein, acridone is functionalized with alkyl side chains containing terminal nitrogen-based moieties at the N10-position and substituted at the C2-position. The products are evaluated for in vitro cytotoxicity against four cancer cell lines: Molt-3, HepG2, A549, and HuCCA-1. The derivative bearing two butyl piperidine side chains at the C2- and N10-positions is the most active, with IC50 values ranging from 2.96 to 9.46 μM. Molecular modeling studies supported the binding of the derivatives to DNA by intercalation, thereby confirming the observed cytotoxic effects.
Preparation of Some New N-Substituted 9,10-Dihydroacridine Derivatives
Charbit, Jean Jacques,Galy, Anne Marie,Galy, Jean Pierre,Barbe, Jacques
, p. 136 - 137 (2007/10/02)
Some new 9,10-dihydroacridines were prepared owing to the well-known central nervous system activity of the structurally related tricyclic molecules.These compounds were easily obtained from 9(10H)-acridinones.
