60547-96-8

Basic information

• Product Name: 6,7-Dimethoxyquinazoline-2,4-diamine
• Synonyms: 6,7-Dimethoxyquinazoline-2,4-diamine;2,4-DiaMino-6,7-diMethoxyquinazoline
• CAS NO: 60547-96-8
• Molecular Formula: C10H12N4O2
• Molecular Weight: 220
• EINECS: 1533716-785-6
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 60547-96-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 489.8 °C at 760 mmHg
• Flash Point: 250 °C
• Appearance: /
• Density: 1.354 g/cm³
• CAS DataBase Reference: 6,7-Dimethoxyquinazoline-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dimethoxyquinazoline-2,4-diamine(60547-96-8)
• EPA Substance Registry System: 6,7-Dimethoxyquinazoline-2,4-diamine(60547-96-8)

Safety Data

• Hazardous Substances Data: 60547-96-8(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Uses

A metabolite of Terazosin (T105000) and a minor metabolite of Prazosin (P702325). Displays high affinity for the α1-Adrenoceptors, important in the treatment of hypertension

Relevant articles and documents

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

The 6 O demethyl and 7 O demethyl analogues of the new antihypertensive drug prazosin [2 [4 (2 furoyl) piperazin 1 yl] 4 amino 6,7 dimethoxyquinazoline hydrochloride] have been unequivocally synthesized via separate ten step reaction sequences starting from isovanillin and vanillin, respectively. The 6 O demethyl derivative was found to be identical with the major prazosin metabolite formed in dog and rat, while the 7 O demethyl derivative was identical with another, less prevalent but significant metabolite. Two minor metabolites of prazosin, 2 (1 piperazinyl) 4 amino 6,7 dimethoxyquinazoline and 2,4 diamino 6,7 dimethoxyquinazoline, are also described. All four metabolites are less potent blood pressure lowering agents in dogs than prazosin but may contribute to its antihypertensive effect, since they account for a major portion of the administered dose.