60548-61-0 Usage
Chemical structure
A chemical compound formed from the esterification of 1,10-decanediol with bisulfamic acid.
Applications
Reagent in organic synthesis
Surfactant in emulsion polymerization
Production of plastics, adhesives, and textile chemicals
Personal care products and pharmaceuticals (due to antimicrobial properties)
Industrial uses
Diverse applications due to its unique properties and versatility.
Functional groups
Contains ester and bisulfamate functional groups.
Physical properties
The specific physical properties (e.g., melting point, boiling point, density, etc.) are not provided in the material.
Chemical properties
The specific chemical properties (e.g., reactivity, stability, etc.) are not provided in the material.
Safety and handling
Information on safety precautions, hazard classification, and handling guidelines is not provided in the material.
Environmental impact
The environmental impact of 1,10-Decanediol, bisulfamate (ester) is not discussed in the material.
Synthesis
The synthesis process for 1,10-Decanediol, bisulfamate (ester) is not described in the material.
Check Digit Verification of cas no
The CAS Registry Mumber 60548-61-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,5,4 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 60548-61:
(7*6)+(6*0)+(5*5)+(4*4)+(3*8)+(2*6)+(1*1)=120
120 % 10 = 0
So 60548-61-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H24N2O6S2/c11-19(13,14)17-9-7-5-3-1-2-4-6-8-10-18-20(12,15)16/h1-10H2,(H2,11,13,14)(H2,12,15,16)
60548-61-0Relevant articles and documents
Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates
Winum, Jean-Yves,Pastorekova, Silvia,Jakubickova, Lydia,Montero, Jean-Louis,Scozzafava, Andrea,Pastorek, Jaromir,Vullo, Daniela,Innocenti, Alessio,Supuran, Claudiu T.
, p. 579 - 584 (2007/10/03)
A series of bis-sulfamates incorporating aliphatic, aromatic, or betulinyl moieties in their molecules was obtained by reaction of the corresponding diols/diphenols with sulfamoyl chloride. The library of bis-sulfamates thus obtained was tested for the inhibition of three physiologically relevant human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, the cytosolic hCA I and II, and the transmembrane, tumor-associated hCA IX. The new compounds reported here inhibited hCA I with KI s in the range of 79 nM-16.45 μM, hCA II with KI s in the range of 6-643 nM, and hCA IX with KI s in the range of 4-5400 nM. Several low nanomolar hCA IX inhibitors were detected, such as 1,8-octylene-bis-sulfamate or 1,10-decylene-bis-sulfamate (KI s in the range of 4-7 nM), which showed good selectivity ratios (in the range of 3.50-3.85) for hCA IX over hCA II inhibition. The most selective hCA IX inhibitor was phenyl-1,4-dimethylene-bis-sulfamate (K I of 61.6 nM), which was a 10.43 times better hCA IX than hCA II inhibitor. These derivatives are interesting candidates for the development of novel antitumor therapies targeting hypoxic tumors, since hCA IX is highly overexpressed in such tissues, and its presence is correlated with bad prognosis and unfavorable clinical outcome.
