60561-39-9

Basic information

• Product Name: methyl (4-chlorophenyl)methylcarbamate
• Synonyms: Carbamic acid, (4-chlorophenyl)methyl-, methyl ester
• CAS NO: 60561-39-9
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.6342
• Mol File: 60561-39-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 279.2°C at 760 mmHg
• Flash Point: 122.6°C
• Density: 1.252g/cm³
• Vapor Pressure: 0.00408mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: methyl (4-chlorophenyl)methylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (4-chlorophenyl)methylcarbamate(60561-39-9)
• EPA Substance Registry System: methyl (4-chlorophenyl)methylcarbamate(60561-39-9)

Safety Data

• Hazardous Substances Data: 60561-39-9(Hazardous Substances Data)

Upstream product

• 940-36-3 (4-chloro-phenyl)-carbamic acid methyl ester 
• 616-38-6 carbonic acid dimethyl ester 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 932-96-7 N-methyl(p-chloroaniline) 

Relevant articles and documents

Selective N-monomethylation of primary anilines with dimethyl carbonate in continuous flow

Selective N-monomethylation of anilines has been achieved under continuous flow conditions using dimethyl carbonate as a green methylating agent in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene. Our methodology takes advantage of the expanded process windows available in the continuous flow regime to safely induce monomethylation in superheated solvents at high pressure. We propose selective N-monomethylation is achieved via an in situ protection-deprotection pathway, which is supported by the observed reactivities of several putative reaction intermediates. The robust and scalable method was applicable to a broad range of primary aniline substrates including ortho-, meta-, and para-substituted anilines, as well as electron-rich and electron-deficient anilines. The synthetic precursor of diazepam, 5-chloro-2-(methylamino)benzophenone, was selectively synthesized under our optimized conditions.