605657-55-4

Basic information

• Product Name: 7-benzyloxy-1-(4-methoxy-phenyl)-3,4-dihydro-isoquinoline
• Synonyms: 7-benzyloxy-1-(4-methoxy-phenyl)-3,4-dihydro-isoquinoline
• CAS NO: 605657-55-4
• Molecular Weight: 343.425
• Mol File: 605657-55-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-benzyloxy-1-(4-methoxy-phenyl)-3,4-dihydro-isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzyloxy-1-(4-methoxy-phenyl)-3,4-dihydro-isoquinoline(605657-55-4)
• EPA Substance Registry System: 7-benzyloxy-1-(4-methoxy-phenyl)-3,4-dihydro-isoquinoline(605657-55-4)

Safety Data

• Hazardous Substances Data: 605657-55-4(Hazardous Substances Data)

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 51179-05-6 2-(4-(benzyloxy)phenyl)ethanamine 
• 2982-55-0 (E)-1-(benzyloxy)-4-(2-nitrovinyl)benzene 

Relevant articles and documents

Structure-based approach to falcipain-2 inhibitors: Synthesis and biological evaluation of 1,6,7-Trisubstituted dihydroisoquinolines and isoquinolines

1,4,7-Trisubstituted isoquinolines were designed, synthesized and evaluated for their inhibition against Plasmodium falciparum cysteine protease falcipain-2. The 1-benzyloxyphenyl-dihydroisoquinoline and -isoquinoline derivatives were found to exhibit better activity against falcipain-2 than their corresponding 1-hydroxyphenyl or 1-methoxyphenyl analogues. The docking scores correlate with the IC50 values of compounds and give a high coefficient correlation of 0.94.