60597-70-8 Usage
General Description
2-Chloro-3-(pyrrolidin-1-ylsulphonyl)pyridine is a specialized chemical compound. Its scientific measurements include a molecular weight of 251.69 g/mol, and a complex formula of C9H10ClN2O2S. Due to its sophisticated structure and properties, this chemical is used predominantly in laboratory settings, likely to manufacture or synthesize other compounds. Detailed information about its physical characteristics, reactivity, toxicity, or potential uses in specific industries or research, might require specialized scientific references or databases. As with many chemicals, handling 2-Chloro-3-(pyrrolidin-1-ylsulphonyl)pyridine should be done with caution, adhering to protective measures and safety guidelines to minimize any risks involved.
Check Digit Verification of cas no
The CAS Registry Mumber 60597-70-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,5,9 and 7 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 60597-70:
(7*6)+(6*0)+(5*5)+(4*9)+(3*7)+(2*7)+(1*0)=138
138 % 10 = 8
So 60597-70-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H11ClN2O2S/c10-9-8(4-3-5-11-9)15(13,14)12-6-1-2-7-12/h3-5H,1-2,6-7H2
60597-70-8Relevant articles and documents
A novel series of [1,2,4]triazolo[4,3-a]pyridine sulfonamides as potential antimalarial agents: In silico studies, synthesis and in vitro evaluation
Karpina, Veronika R.,Kovalenko, Svitlana S.,Kovalenko, Sergiy M.,Drushlyak, Oleksandr G.,Bunyatyan, Natalya D.,Georgiyants, Victoriya A.,Ivanov, Vladimir V.,Langer, Thierry,Maes, Louis
, (2020/10/18)
For the development of new and potent antimalarial drugs, we designed the virtual library with three points of randomization of novel [1,2,4]triazolo[4,3-a]pyridines bearing a sulfonamide fragment. The library of 1561 compounds has been investigated by both virtual screening and molecular docking methods using falcipain-2 as a target enzyme. 25 chosen hits were synthesized and evaluated for their antimalarial activity in vitro against Plasmodium falciparum. 3-Ethyl-N-(3-fluorobenzyl)-N-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine-6-sulfonamide and 2-(3-chlorobenzyl)-8-(piperidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one showed in vitro good antimalarial activity with inhibitory concentration IC50 = 2.24 and 4.98 μM, respectively. This new series of compounds may serve as a starting point for future antimalarial drug discovery programs.
