606-67-7

Basic information

• Product Name: Adenosine 5-(tetrahydrogen triphosphate), tetrasodium salt
• CAS NO: 606-67-7
• Molecular Formula: C₂₀H₂₈N₁₀Na₄O₂₆P₆
• Molecular Weight: 551.148
• Mol File: 606-67-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 951.4°Cat760mmHg
• Flash Point: 529.2°C
• Density: g/cm³
• CAS DataBase Reference: Adenosine 5-(tetrahydrogen triphosphate), tetrasodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine 5-(tetrahydrogen triphosphate), tetrasodium salt(606-67-7)
• EPA Substance Registry System: Adenosine 5-(tetrahydrogen triphosphate), tetrasodium salt(606-67-7)

Safety Data

• Hazardous Substances Data: 606-67-7(Hazardous Substances Data)

Upstream product

• 53355-60-5 adenosine 5'-trimetaphosphate 
• 4578-31-8 adenosine-5'-monophosphate disodium salt 
• 1172-42-5 adenosine-5′-diphosphate trisodium salt 
• 1577254-51-3 adenosine 5′-phosphoropiperidate triethylammonium salt 
• 33962-65-1 adenosine 5'-phosphate triethylammonium salt 
• 79670-88-5 C₁₀H₁₆N₅O₁₃P₃*4H₃N 
• 7659-75-8 adenosine (5'-phosphoro-1-piperidinide) 
• 58-61-7 adenosine 
• 34051-17-7 C₁₀H₁₂Cl₂N₅O₅P 

Downstream Products

• 1172-42-5 adenosine diphosphate disodium salt 
• 61-19-8 5'-adenosine monophosphate 
• 58-64-0 adenosine 5'-diphosphate 

Relevant articles and documents

Concurrent Prebiotic Formation of Nucleoside-Amidophosphates and Nucleoside-Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization

Polymerization of nucleic acids in biology utilizes 5′-nucleoside triphosphates (NTPs) as substrates. The prebiotic availability of NTPs has been unresolved and other derivatives of nucleoside-monophosphates (NMPs) have been studied. However, this latter approach necessitates a change in chemistries when transitioning to biology. Herein we show that diamidophosphate (DAP), in a one-pot amidophosphorylation-hydrolysis setting converts NMPs into the corresponding NTPs via 5′-nucleoside amidophosphates (NaPs). The resulting crude mixture of NTPs are accepted by proteinaceous- and ribozyme-polymerases as substrates for nucleic acid polymerization. This phosphorylation also operates at the level of oligonucleotides enabling ribozyme-mediated ligation. This one-pot protocol for simultaneous generation of NaPs and NTPs suggests that the transition from prebiotic-phosphorylation and oligomerization to an enzymatic processive-polymerization can be more continuous than previously anticipated.

Efficient synthesis of nucleoside 5′-triphosphates and their β,γ-bridging oxygen-modified analogs from nucleoside 5′-phosphates

Thirteen nucleoside 5′-triphosphates (NTPs) and their β,γ-bridging oxygen-modified analogs (β,γ-CX 2-NTPs, X = H, F, Cl, and Br) have been efficiently synthesized from nucleoside 5′-phosphoropiperidates with 4,5-dicyanoimidazole as the activator. A high-yielding and chromatography-free protocol for the preparation of both natural and base-modified nucleoside 5′-phosphoropiperidates from the corresponding nucleoside 5′-phosphates was also developed.

Convenient synthesis of nucleoside 5′-triphosphates for RNA transcription

By generating a selective phosphitylating reagent in situ, nucleoside 5′-triphosphates can be conveniently synthesized in one pot. This novel strategy without nucleoside protection has been developed to largely simplify synthesis of the nucleoside triphosphates. This demonstrated principle can be applied to the 5′-triphosphate synthesis of both native and modified nucleosides.