60633-27-4

Basic information

• Product Name: Benzene, 1,5-dichloro-3-iodo-2-methoxy-
• CAS NO: 60633-27-4
• Molecular Formula: C7H5Cl2IO
• Molecular Weight: 302.927
• Mol File: 60633-27-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1,5-dichloro-3-iodo-2-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,5-dichloro-3-iodo-2-methoxy-(60633-27-4)
• EPA Substance Registry System: Benzene, 1,5-dichloro-3-iodo-2-methoxy-(60633-27-4)

Safety Data

• Hazardous Substances Data: 60633-27-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 2040-83-7 2,4-dichloro-6-iodophenol 
• 120-83-2 2,4-dichlorophenol 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 220970-33-2 4-chloro-2-dichloroiodanyl-anisole 
• 529-28-2 4-iodoanisol 

Downstream Products

• 56680-89-8 3,5-dichloro-2-methoxyphenol 

Relevant articles and documents

NOVEL THYROMIMETICS

Compounds are provided having the structure of Formula (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R2, X1, X2, Y1, and Y2 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Efficient and reliable iodination and o-Methylation of fluorinated phenols

Fluorinated phenols and other electron-deficient phenolic substrates are efficiently and cleanly iodinated by an iodine/ iodide mixture employing alkaline conditions. This protocol turned out to be the most practical for the generation of such highly fluorinated iodophenols. For later application in coupling processes the protection of the phenolic hydroxy moiety is often required. Therefore, a practical iodination and subsequent methylation sequence was elaborated providing the highly fluorinated anisoles with good to excellent yields. The developed method is applicable for a broad scope of fluorinated phenols and analogues.