60657-74-1

Basic information

• Product Name: 3-[methyl(phenyl)amino]-3-oxopropanoic acid
• CAS NO: 60657-74-1
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.1992
• Mol File: 60657-74-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 358.2°C at 760 mmHg
• Flash Point: 170.5°C
• Density: 1.269g/cm³
• Vapor Pressure: 9.36E-06mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 3-[methyl(phenyl)amino]-3-oxopropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[methyl(phenyl)amino]-3-oxopropanoic acid(60657-74-1)
• EPA Substance Registry System: 3-[methyl(phenyl)amino]-3-oxopropanoic acid(60657-74-1)

Safety Data

• Hazardous Substances Data: 60657-74-1(Hazardous Substances Data)

Upstream product

• 39581-30-1 3-(N-methyl-N-phenylamino)-3-oxopropanenitrile 
• 124-38-9 carbon dioxide 
• 84088-88-0 methyl 3-(N-methyl-N-phenylamino)-3-oxopropanoate 
• 59050-15-6 ethyl 3-(N-methyl-N-phenylamino)-3-oxopropionate 
• 100-61-8 N-methylaniline 

Downstream Products

• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 
• 497070-78-7 N-methyl-N-phenylmalonamic acid 3-trimethylsilanylprop-2-ynyl ester 
• 497070-77-6 2-diazo-N-methyl-N-phenylmalonamic acid 3-trimethylsilanylprop-2-ynyl ester 
• 40335-01-1 2-methoxy-1-methyl-1H-quinolin-4-one 
• 32262-18-3 N-methyl-4-methoxyquinolin-2(1H)-one 
• 1373442-45-5 1-benzyl-1'-methyl-3,3'-spirobi[indoline]-2,2'-dione 
• 1373442-85-3 N⁽¹⁾-methyl-N⁽¹⁾-phenyl-N⁽³⁾,N⁽³⁾-dipropylmalonamide 
• 1373442-89-7 2-hydroxy-N⁽¹⁾-methyl-N⁽¹⁾-phenyl-N⁽³⁾,N⁽³⁾-dipropylmalonamide 
• 1373442-78-4 N⁽¹⁾,N⁽³⁾-dimethyl-N⁽¹⁾-(4-nitrophenyl)-N⁽³⁾-phenylmalonamide 

Relevant articles and documents

Asymmetric synthesis of tetrahydropyran[3,2-c]quinolinones via an organocatalyzed formal [3 + 3] annulation of quinolinones and MBH 2-naphthoates of nitroolefin

An efficient asymmetric and enantio-swithchable organocatalytic [3 + 3] annulation reaction using MBH-2-naphthoates of nitroalkenes and 4-hydroxyquinolin-2(1H)-ones has been developed. Densely substituted tetrahydropyrano[3,2-c]quinolinones scaffolds with two adjacent stereogenic centers are obtained with high yield (up to 95% yield) and good stereoselectivities (up to >20:1 dr and 96% ee) in an enantio-switchable manner. Furthermore, gram scale synthesis was achieved and the nitro group could easily transform into an amino group without any appreciable loss in the diastereo- and enantioselectivity.

OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS

Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.

N3-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases

A family of thieno[3,2-b]pyridine based small molecule inhibitors of c-Met and VEGFR2 were designed based on lead structure 2. These compounds were shown to have IC50 values in the low nanomolar range in vitro and were efficacious in human tumo