60666-01-5

Basic information

• Product Name: (RS)-N-phthaloyl-p-nitrophenylalanine
• Synonyms: (RS)-N-phthaloyl-p-nitrophenylalanine
• CAS NO: 60666-01-5
• Molecular Weight: 340.292
• Mol File: 60666-01-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (RS)-N-phthaloyl-p-nitrophenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-N-phthaloyl-p-nitrophenylalanine(60666-01-5)
• EPA Substance Registry System: (RS)-N-phthaloyl-p-nitrophenylalanine(60666-01-5)

Safety Data

• Hazardous Substances Data: 60666-01-5(Hazardous Substances Data)

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 855633-22-6 (4-nitro-benzyl)-phthalimido-malonic acid diethyl ester 
• 101445-16-3 N-(2-carboxy-benzoyl)-4-nitro-phenylalanine 
• 85-44-9 phthalic anhydride 
• 1991-83-9 4-nitrophenylalanine 

Downstream Products

• 98722-37-3 4-nitro-N,N-phthaloyl-DL-phenylalanin-ethyl ester 
• 131175-70-7 (R)-N-phthaloyl-p-nitrophenylalanine 
• 17451-66-0 N-phthaloyl-3-(4-nitrophenyl)-(S)-alanine 
• 178421-62-0 N-tert-Butyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(4-nitro-phenyl)-propionamide 
• 6957-95-5 4-nitro-N,N-phthaloyl-D-phenylalanin-ethyl ester 
• 17451-67-1 N-phthalimido-4-nitro-L-phenylalanine ethyl ester 
• 1319744-31-4 3-(4-nitrophenyl)-N-(quinolin-8-yl)propanamide 

Relevant articles and documents

NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF

Novel TRF1 modulators and analogues thereof. There is provided compounds of Formula I, wherein R, R1, R2 and X have meanings written in the description. Such compounds are useful as TRF1 inhibitors and, for that reason, as medicaments, in the treatment of cancer, particularly high cancer stem cell cancer like glioblastoma and lung cancer, and can be also useful for the development of additional TRF1 inhibitors and increasing knowledge about TRF1 activity.

Neighbouring group effects promote substitution reactions over elimination and provide a stereocontrolled route to chloramphenicol

In reactions of β-brominated valine and p-nitrophenylalanine derivatives to give β-hydroxy amino acid derivatives the carboxyl group, when protected as an amide, exerts a neighbouring group effect to facilitate the substitution process, and reduce competing elimination reactions. As a consequence of the effect, the (2R,3R)- and (2R,3S)-stereoisomers of 3-bromo-N-tert-butyl-N(α)-phthaloyl-p-nitrophenylalaninamide both react to give (2S,3R)-3-hydroxy-N-tert-butyl-N(α)-phthaloyl-p-nitrophenylalaninamid e, providing a stereoconvergent route to chloramphenicol.