60668-55-5

Basic information

• Product Name: L-Phe-L-Ala(P)
• CAS NO: 60668-55-5
• Molecular Weight: 272.241
• Mol File: 60668-55-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Phe-L-Ala(P)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phe-L-Ala(P)(60668-55-5)
• EPA Substance Registry System: L-Phe-L-Ala(P)(60668-55-5)

Safety Data

• Hazardous Substances Data: 60668-55-5(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 60687-36-7 (R)-(1-aminoethyl)phosphonic acid 
• 60668-54-4 (1R)-1-[(N-benzyloxycarbonyl-L-phenylalanyl)amino]-ethylphosphonic acid 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 

Relevant articles and documents

Investigation of Amide Bond Formation during Dehydrophos Biosynthesis

Dehydrophos is a tripeptide phosphonate antibiotic produced by Streptomyces luridus. Its biosynthetic pathway involves the use of aminoacyl-tRNA (aa-tRNA) for amide bond formation. The first amide bond during biosynthesis is formed by DhpH-C, a peptidyltransferase that utilizes Leu-tRNALeu. DhpH-C is a member of a burgeoning family of natural product biosynthetic enzymes that make use of aa-tRNA outside of canonical translation activities in the cell. Here, we used site-directed mutagenesis of both DhpH-C and tRNALeu to investigate the enzyme mechanism and substrate specificity, respectively, and analyzed the substrate scope for the production of a set of dipeptides. DhpH-C appears to recognize both the amino acyl group on the tRNA and the tRNA acceptor stem, and the enzyme can accept other hydrophobic residues, in addition to leucine. These results contribute to a better understanding of enzyme-aa-tRNA interactions and the growing exploration of aa-tRNA usage beyond translation.