60669-22-9Relevant articles and documents
Parallel, stereoselective syntheses of both enantiomers of muricatacin and their sulfur and nitrogen relatives using the silyloxy diene-based methodology
Rassu,Pinna,Spanu,Zanardi,Battistini,Casiraghi
, p. 4513 - 4517 (1997)
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A yellow star longicorn pheromone preparation method (by machine translation)
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Paragraph 0101; 0102; 0103, (2018/09/21)
The present invention provides a preparation method of huang xing longicorn pheromone, the present invention relates to chiral compound compound 1 as the initial reactant, and selecting different quaternary phosphonium salt, can be efficient and rapid growth of the aliphatic, obtained with high stereo specific hued rectangle which bears longicorn pheromone. The present invention provides a preparation method of the operation is simple, short synthetic route, and the goal overall yield of the product is high, up to 20% (as the compound 1 is calculated as the initiator), is suitable for the large scale synthesis, the beetles of the pheromone huang xing active research, biological experiment, agricultural applications and pest control of important significance. (by machine translation)
Development of sulfonamide AKT PH domain inhibitors
Ahad, Ali Md.,Zuohe, Song,Du-Cuny, Lei,Moses, Sylvestor A.,Zhou, Li Li,Zhang, Shuxing,Powis, Garth,Meuillet, Emmanuelle J.,Mash, Eugene A.
supporting information; experimental part, p. 2046 - 2054 (2011/05/05)
Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations. To examine the effects of structural modification, a set of sulfonamides related to the lead compound was designed, synthesized, and tested for binding to the expressed PH domain of AKT using a surface plasmon resonance-based competitive binding assay. Cellular activity was determined by means of an assay for pAKT production and a cell killing assay using BxPC-3 cells. The most active compounds in the set are lipophilic and possess an aliphatic chain of the proper length. Results were interpreted with the aid of computational modeling. This paper represents the first structure-activity relationship (SAR) study of a large family of AKT PH domain inhibitors. Information obtained will be used in the design of the next generation of inhibitors of AKT PH domain function.