60682-97-5Relevant articles and documents
Pd(OAc)2 immobilized on imine-functionalized microporous covalent triazine polymer as efficient heterogeneous catalyst for Mizoroki–Heck cross-coupling reaction
Sadhasivam, Velu,Mathappan, Mariyappan,Harikrishnan, Muniyasamy,Chithiraikumar, Chinnadurai,Murugesan, Sepperumal,Siva, Ayyanar
, p. 2853 - 2866 (2018/02/16)
A template consisting of Pd(OAc)2 immobilized on imine-functionalized microporous covalent triazine polymer network (Pd/TATAE) was synthesized and found to be an efficient and recyclable heterogeneous solid catalyst for Mizoroki–Heck C–C coupling of styrene with substituted aryl halides under mild reaction conditions and without addition of any ligand or additives. Furthermore, Pd/TATAE could be recycled for nine consecutive cycles with minor loss of catalytic activity. Finally, the Pd/TATAE catalyst showed good catalytic activity with excellent yield of 96?% and high turnover number of 3349.
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: A systematic investigation of the influence of linker and cationic heads over affinity and selectivity
Conejo-García, Ana,Pisani, Leonardo,Del Carmen Nú?ez, Maria,Catto, Marco,Nicolotti, Orazio,Leonetti, Francesco,Campos, Joaquín M.,Gallo, Miguel A.,Espinosa, Antonio,Carotti, Angelo
body text, p. 2627 - 2645 (2011/06/21)
A molecular library of quaternary ammonium salts (QASs), mainly composed of symmetrical bis-quaternary heterocyclic bromides exhibiting choline kinase (ChoK) inhibitory activity, were evaluated for their ability to inhibit acetyl- and butyrylcholinesterase (AChE and BChE, respectively). The molecular framework of QASs consisted of two positively charged heteroaromatic (pyridinium or quinolinium) or sterically hindered aliphatic (quinuclidinium) nitrogen rings kept at an appropriate distance by lipophilic rigid or semirigid linkers. Many homodimeric QASs showed AChE and BChE inhibitory potency in the nanomolar range along with a low enzymatic selectivity. Computational studies on AChE, BChE, and ChoK allowed identification of the key molecular determinants for high affinity and selectivity over either one of the three enzymes and guided the design of a hybrid bis-QAS (56) exhibiting the highest AChE affinity (IC50 = 15 nM) and selectivity over BChE and ChoK (SI = 50 and 562, respectively) and a promising pharmacological potential in myasthenia gravis and neuromuscular blockade.
Control of the intramolecular [2+2] photocycloaddition in a bis-stilbene macrocycle
Xu, Yuewen,Smith, Mark D.,Krause, Jeanette A.,Shimizu, Linda S.
supporting information; experimental part, p. 4874 - 4877 (2009/09/30)
(Chemical Equation Presented) The intramolecular [2+2] photocyclization of a bis-stilbene macrocycle was studied. The reaction can be controlled by the insertion and removal of urea protecting groups. Upon UV-irradiation in both the solid state and DMSO s
