60705-72-8

Basic information

• Product Name: Phosphonic acid, methyl-, bis[4-(1,1-dimethylethyl)phenyl] ester
• CAS NO: 60705-72-8
• Molecular Formula: C21H29O3P
• Molecular Weight: 360.433
• Mol File: 60705-72-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, methyl-, bis[4-(1,1-dimethylethyl)phenyl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, methyl-, bis[4-(1,1-dimethylethyl)phenyl] ester(60705-72-8)
• EPA Substance Registry System: Phosphonic acid, methyl-, bis[4-(1,1-dimethylethyl)phenyl] ester(60705-72-8)

Safety Data

• Hazardous Substances Data: 60705-72-8(Hazardous Substances Data)

Upstream product

• 676-97-1 methylphosphonic acid dichloroanhydride 
• 98-54-4 para-tert-butylphenol 
• 6395-57-9 O,O-di-4-nitrophenyl methylphosphonate 

Downstream Products

• 993-13-5 methylphosphonic acid 
• 1625-91-8 4,4'-di-tert-butylbiphenyl 

Relevant articles and documents

1,8-Diazabicyclo[5.4.0]undecene mediated transesterification of p-nitrophenyl phosphonates: A novel route to phosphono esters

DBU (1,8-diazabicyclo[5.4.0]undecene) was found to efficiently mediate the transesterification of p-nitrophenyl (PNP) phosphonates by various alcohols. The reactions of bis-PNP phosphonates in the presence of DBU, using both primary and secondary alcohols, phenols and amines, proceed rapidly and with high yield to afford the corresponding monoalkyl/aryl mono-PNP phosphonates as sole products (1, Scheme 2). The resulting monoalkyl/aryl mono-PNP phosphonates can be further reacted with a second alcohol to give the corresponding differently disubstituted phosphonates 3, or selectively hydrolysed to yield the monoalkyl/aryl phosphonic acids 2. We have applied this chemistry to the preparation of a series of phosphono ester transition state analogues 11a-e (Scheme 3) that were used as haptens for raising catalytic antibodies.