60754-33-8

Basic information

• Product Name: Butanoic acid, 2-(phenylmethylene)-, ethyl ester, (E)-
• CAS NO: 60754-33-8
• Molecular Formula: C13H16O2
• Molecular Weight: 204.269
• Mol File: 60754-33-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-(phenylmethylene)-, ethyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-(phenylmethylene)-, ethyl ester, (E)-(60754-33-8)
• EPA Substance Registry System: Butanoic acid, 2-(phenylmethylene)-, ethyl ester, (E)-(60754-33-8)

Safety Data

• Hazardous Substances Data: 60754-33-8(Hazardous Substances Data)

Upstream product

• 89638-15-3 ethyl 2-(methyldiphenylsilyl)-3-phenylpropanoate 
• 100-52-7 benzaldehyde 
• 78-40-0 triethyl phosphate 
• 2417-93-8 propyllithium 
• 105-58-8 Diethyl carbonate 
• 18812-51-6 diethyl propylphosphonate 
• 533-68-6 2-bromobutyric acid ethyl ester 
• 105479-98-9 ethyl 2-(acetoxy(phenyl)methyl)acrylate 
• 52089-54-0 ethyl 2-hydroxybutyrate 
• 162213-05-0 ethyl 2-{[(trifluoromethyl)sulphonyl]oxy}butanoate 
• 105-54-4 butanoic acid ethyl ester 
• 831-91-4 Benzyl phenyl sulfide 
• 7693-31-4 α-chlorobenzyl phenyl sulfide 
• 75-24-1 trimethylaluminum 

Downstream Products

• 3571-78-6 2,4-Dioxo-5-ethyl-6-phenyl-tetrahydro-1,3-thiazin 
• 1408163-11-0 (S)-ethyl 2-benzylbutanoate 
• 2983-36-0 ethyl 2-benzylbutanoate 
• 56407-97-7 (E)-2-benzylidenebutan-1-ol 
• 26197-64-8 (E)-2-benzylidenebutanoic acid 

Relevant articles and documents

Copper-Photocatalyzed Contra-Thermodynamic Isomerization of Polarized Alkenes

The contra-thermodynamic isomerization of α- and β-substituted cinnamate derivatives catalyzed by the Cu(OAc)2/rac-BINAP complex under blue light irradiation is reported. The use of an oxazolidinone template, which favored the complexation of the copper catalyst to the substrate, allowed the E → Z isomerization of the catalytically formed chromophore under simple and robust reaction conditions in good to excellent ratios. The mechanism of this process based on the transient formation of a chromophore was also studied.

Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization

Inspired by the dicationic nature of the electrophilic fluorinating reagent, Selectfluor (1), we rationally designed a series of dicarboxylic acid precatalysts (2), which, when deprotonated, act as anionic phase-transfer catalysts for asymmetric fluorination of alkenes. Among them, 2a having the shortest linker moiety efficiently catalyzed unprecedented 6-endo-fluoro-cyclization of various allylic amides, affording fluorinated dihydrooxazine compounds with high enantioselectivity (up to 99% ee). In addition to cyclic substrates, acyclic trisubstituted alkenes underwent the reaction with good diastereoselectivity, whereas low diastereoselectivity was observed for linear disubstituted alkenes. Results suggest that the reaction proceeds via a fluoro-carbocation intermediate.

Mapping the mechanism of nickel-ferrophite catalysed methylation of baylis-hillman-derived SN2′ electrophiles

Enantioselective Ni-catalysed methylation of Baylis-Hillman-derived allylic electrophiles in the presence of ferrophite ligands has been investigated computationally and experimentally. The sense and degree of enantioselectivity attained is independent of both the leaving group and the isomeric structure of the initial allylic halide. DFT studies support the selective formation of a limited number of energetically favoured anti and syn π-allyl intermediates. The observed regio- and enantioselectivity can be rationalised based on the energetics of these structures.