60762-57-4 Usage
Description
Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 μM independent of MAO-A activity.
Uses
Antidepressive;Monoamine oxidase inhibitor
Biological Activity
A highly selective reversible inhibitor of monoamine oxidase type A.
Check Digit Verification of cas no
The CAS Registry Mumber 60762-57-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,7,6 and 2 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 60762-57:
(7*6)+(6*0)+(5*7)+(4*6)+(3*2)+(2*5)+(1*7)=124
124 % 10 = 4
So 60762-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H18N2/c1-10-5-6-14-12(9-10)11-3-2-4-13-15(11)17(14)8-7-16-13/h5-6,9,13,16H,2-4,7-8H2,1H3/p+1/t13-/m0/s1
60762-57-4Relevant articles and documents
Novel synthetic method of pirlindole
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, (2020/04/17)
The invention belongs to the technical field of medicines, and relates to a synthetic method of pirlindole. According to the method, p-methylphenylhydrazine hydrochloride and 1,2-cyclohexanedione areused as initial raw materials, and conventional methods such as ring closing, condensation, chlorination, alkylation and reduction are carried out to synthesize the pirlindole. The key step of the method comprises ring closing reaction of p-methylphenylhydrazine hydrochloride and 1,2-cyclohexanedione under the action of glacial acetic acid and hydrochloric acid to obtain a key intermediate 6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-one. The method has the advantages of high yield, cheap and easily available raw materials and lower reaction cost, and is suitable for industrial production.
