6077-18-5

Basic information

• Product Name: 2-Propen-1-one, 1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-
• Synonyms: 2-Propen-1-one, 1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-;1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one;2,2'-Dihydroxy-5'-chlor-chalkon
• CAS NO: 6077-18-5
• Molecular Formula: C₁₅H₁₁ClO₃
• Molecular Weight: 274.69904
• Mol File: 6077-18-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 222-223 °C
• Boiling Point: 486.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.382±0.06 g/cm3(Predicted)
• PKA: 7.14±0.43(Predicted)
• CAS DataBase Reference: 2-Propen-1-one, 1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-(6077-18-5)
• EPA Substance Registry System: 2-Propen-1-one, 1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-(6077-18-5)

Safety Data

• Hazardous Substances Data: 6077-18-5(Hazardous Substances Data)

Upstream product

• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 90-02-8 salicylaldehyde 
• 876-27-7 4-chlorophenyl acetate 
• 5533-04-0 2-(methoxymethoxy)benzaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 3505-43-9 6-chloro-2-(2-hydroxyphenyl)-4H-chromen-4-one 
• 160748-57-2 2-[(E)-1-[(E)-2-Amino-ethylimino]-3-(2-hydroxy-phenyl)-allyl]-4-chloro-phenol 
• 86882-45-3 4-Chloro-2-[2-(2-hydroxy-phenyl)-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[b][1,4]thiazepin-4-yl]-phenol 
• 100914-75-8 6-chloro-3-hydroxy-2-(2-hydroxy-phenyl)-chromen-4-one 
• 108718-33-8 6-chloro-2'-hydroxyflavanone 

Relevant articles and documents

Phototransformations of some 3-cyclohexenyloxychromenones: Synthesis of Spirocyclic compounds

The phototransformation of the 3-cyclohexenyloxychromenones by irradiation with a pyrex-filtered light from a 125 W Hg vapor lamp under an inert atmosphere into the spirocyclic fused xanthenones was described. The efficacy of the protocol depended upon th

COMPOSITIONS FOR INHIBITING ANDROGEN DEPENDENT OR INDEPENDENT PROSTATE CANCER CELLS AND PHARMACEUTICAL FORMULATIONS OF PROSTATE CANCER CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide compositions for inhibiting androgen dependent or independent prostate cancer cells which are used for prostate cancer, inhibit activation of androgen receptors, are effective for inhibiting the proliferation of androgen dependent or independent prostate cancer, inhibit the action even if AR-V7 has expressed, and are effective also to anticancer drug resistant cell lines; and to provide pharmaceutical formulations of prostate cancer using the same. SOLUTION: A composition for inhibiting androgen dependent or independent prostate cancer cells comprises an α,β-saturated or unsaturated ketone derivative represented by the following chemical formula (1) or a pharmaceutically acceptable salt thereof. (X- represents a hydrocarbon aromatic ring group or an aromatic heterocyclic group, both or either of Y1- and Y2- are a hydrocarbon aromatic ring group or an aromatic heterocyclic group and the other is a hydrogen atom, Z= represents an atom or a functional group which forms or generates a ketone group, a thioketone group, an imino group, or an oxime group together with a bonding carbon atom, Y3- is a hydrogen atom, a perhalogeno hydrocarbon group or the like.) The pharmaceutical formulation of prostate cancer contains this composition. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles

A convenient approach for the synthesis of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized heterocyclic rings (eight-, nine-, ten- and eleven-membered rings) containing two oxygen atoms from flavonols through alkylation using different dibromoalkanes was described. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 6c. The synthesized compounds were evaluated for their in vitro antimicrobial activity. Docking studies were carried out for most active two compounds 6f and 6i.