60770-24-3

Basic information

• Product Name: Benzoic acid, 2-(carboxymethoxy)-5-fluoro-
• Synonyms: Benzoic acid,2-(carboxymethoxy)-5-fluoro;2-(carboxymethoxy)-5-fluoro-benzoic acid;O-Carboxymethyl-5-fluorsalicylsaeure
• CAS NO: 60770-24-3
• Molecular Formula: C9H7FO5
• Molecular Weight: 214.15
• Mol File: 60770-24-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(carboxymethoxy)-5-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(carboxymethoxy)-5-fluoro-(60770-24-3)
• EPA Substance Registry System: Benzoic acid, 2-(carboxymethoxy)-5-fluoro-(60770-24-3)

Safety Data

• Hazardous Substances Data: 60770-24-3(Hazardous Substances Data)

Upstream product

• 391-92-4 methyl 5-fluoro-2-hydroxybenzoate 
• 1216994-21-6 C₁₁H₁₁FO₅ 
• 796851-83-7 methyl-5-fluoro-2-(ethoxy-2-oxoethoxy)benzoate 
• 821786-90-7 3-{1-[2-(1-benzofuran-3-yl)ethyl]-1,2,3,6-tetrahydro-4-pyridinyl}-1H-indole 

Downstream Products

• 60770-49-2 5-fluoro-2,3-dihydro-1-benzofuran-3-one 

Relevant articles and documents

Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties

A virtual screening campaign aimed at finding structurally new compounds active at 5-HT6R provided a set of candidates. Among those, one structure, 4-(5-{[(2-{5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)amino]methyl}furan-2-yl)phenol (1, 5-HT6R Ki = 91 nM), was selected as a hit for further optimization. As expected, the chemical scaffold of selected compound was significantly different from all the serotonin receptor ligands published to date. Synthetic efforts, supported by molecular modelling, provided 43 compounds representing different substitution patterns. The derivative 42, 4-(5-{[(2-{5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)amino]methyl}furan-2-yl)phenol (5-HT6R Ki = 25, 5-HT2AR Ki = 32 nM), was selected as a lead and showed a good brain/plasma concentration profile, and it reversed phencyclidine-induced memory impairment. Considering the unique activity profile, the obtained series might be a good starting point for the development of a novel antipsychotic or antidepressant with pro-cognitive properties.

BENZOFURANYL- AND BENZOTHIENYL- PIPERAZINYL QUINOLINES AND METHODS OF THEIR USE

Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.

BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AND METHODS OF THEIR USE

Benzofuranyl-and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.