6078-17-7

Basic information

• Product Name: BERBAMINE DIHYDROCHLORIDE
• Synonyms: BERBENINE;BERBAMINE DIHYDROCHLORIDE;BERBAMINE HCL;BERBAMINE 2HCL;(4aS,16aR)-3,4,4a,5,16a,17,18,19-Octahydro-21,22,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol hydrochloride;6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol dihydrochloride;Hydrochloride Berbamine;NH26773
• CAS NO: 6078-17-7
• Molecular Formula: C₃₇H₄₀N₂O₆*2ClH
• Molecular Weight: 665.65
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 6078-17-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 250-253 °C(lit.)
• Boiling Point: 744.4 °C at 760 mmHg
• Flash Point: 404 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: ≥68 mg/mL in DMSO; ≥10.68 mg/mL in H2O; ≥4.57 mg/mL in EtOH
• CAS DataBase Reference: BERBAMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BERBAMINE DIHYDROCHLORIDE(6078-17-7)
• EPA Substance Registry System: BERBAMINE DIHYDROCHLORIDE(6078-17-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 6078-17-7(Hazardous Substances Data)

Usage

Description

Berbamine Dihydrochloride is a chemical compound derived from the berberine alkaloid family, which is found in various plants. It is known for its potent biological activities and potential therapeutic applications.

Uses

Used in Pharmaceutical Industry:
Berbamine Dihydrochloride is used as a reactant for the preparation of anti-leukemia active berbamine derivatives. These derivatives have shown significant potential in the treatment of leukemia, a type of blood cancer.
Used in Anti-inflammatory Applications:
Berbamine Dihydrochloride is used as an anti-inflammatory agent for its ability to inhibit the NF-κB and MAPK signaling pathways. By targeting these pathways, it can help reduce inflammation and alleviate symptoms associated with various inflammatory conditions.

Biological Activity

extracted from berberidis;store the product in sealed, cool and dry condition

Upstream product

• 478-61-5 berbamine 

Downstream Products

• 1172120-94-3 C₄₂H₄₂N₂O₈ 
• 1172120-93-2 C₄₅H₄₃F₃N₂O₇ 
• 79703-41-6 12-ethoxy-6,7,6'-trimethoxy-2,2'-dimethyl-berbamane 
• 1172120-81-8 O-((6-chloropyridin-3-yl)methyl)berbamine 
• 1172120-80-7 C₄₇H₅₂N₂O₉ 
• 1333259-81-6 C₄₅H₄₅ClN₂O₇ 
• 1172120-82-9 C₄₂H₄₈N₂O₇ 
• 1172120-77-2 C₄₄H₄₆N₂O₆ 
• 1172120-85-2 C₄₄H₄₃ClN₂O₇ 
• 1172120-90-9 C₄₅H₄₃F₃N₂O₇ 
• 114784-57-5 C₄₇H₅₀N₂O₁₀ 
• 111954-08-6 C₄₄H₄₄N₂O₇ 
• 114784-58-6 O-(4-chlorobenzoyl)berbamine 
• 114784-56-4 C₄₅H₄₆N₂O₈ 

Relevant articles and documents

Isoquinoline medicine and its preparation and use

The invention relates to an isoquinoline drug, and its preparation method and application. The molecular formula of the drug is C37H40N2O6.2HCl.nH2O, wherein n is 3 or 3.5. With good storage stability, the isoquinoline drug is suitable for application in preparation of medicines promoting proliferation of white blood cells, preventing white blood cell decrease after cancer radiotherapy and chemotherapy, resisting inflammation, resisting tuberculosis, resisting silicosis, resisting tumor, reducing blood pressure, resisting myocardial anoxia and ischemia, resisting arrhythmia, and treating or preventing other diseases.