608136-11-4

Basic information

• Product Name: N-(6-(diethylamino)-9-(2-(piperazine-1-carbonyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium
• Synonyms: N-(6-(diethylamino)-9-(2-(piperazine-1-carbonyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium
• CAS NO: 608136-11-4
• Molecular Weight: 511.687
• Mol File: 608136-11-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(6-(diethylamino)-9-(2-(piperazine-1-carbonyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-(diethylamino)-9-(2-(piperazine-1-carbonyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium(608136-11-4)
• EPA Substance Registry System: N-(6-(diethylamino)-9-(2-(piperazine-1-carbonyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium(608136-11-4)

Safety Data

• Hazardous Substances Data: 608136-11-4(Hazardous Substances Data)

Upstream product

• 1362851-21-5 rhodamine-N-piperazine-N-Boc 
• 81-88-9 rhodamine B 
• 110-85-0 piperazine 
• 1118784-85-2 rhodamine B 

Downstream Products

• 608136-12-5 rhodamine B 4-(3-carboxypropionyl)piperazine amide 
• 608136-16-9 1-(rhodamine B)-4-(2′-chloroacetyl)-piperazine amide 
• 608136-13-6 rhodamine B 4-(3-hydroxypropyl)piperazine amide 
• 608136-14-7 rhodamine B 4-(3-(succinimidooxycarbonyloxy)propyl)piperazine amide 
• 1309434-53-4 N-(6-(diethylamino)-9-(2-(4-(prop-2-yn-1-yl)piperazine-1-carbonyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium 
• 1604837-32-2 rhodamine B 3-(2-(2-(4-((di(prop-2-yn-1-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)-1-(piperazin-1-yl)propan-1-one 
• 1604837-35-5 rhodamine B 3-(4-((di(prop-2-yn-1-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)-1-(piperazin-1-yl)propan-1-one 
• 1604837-30-0 rhodamine B 3-(2-(2-azidoethoxy)ethoxy)-1-(piperazin-1-yl)propan-1-one 
• 1604837-34-4 rhodamine B 3-azido-1-(piperazin-1-yl)propan-1-one 
• 1373502-25-0 C₃₉H₄₉N₈O₄⁽¹⁺⁾ 

Relevant articles and documents

Photoactivatable Fluorescent Tags for Dual-Modality Positron Emission Tomography Optical Imaging

Fluorescent protein conjugates are vital tools in a wide range of scientific disciplines from basic biochemical research to applications in clinical pathology and intraoperative surgery. We report the synthesis and characterization of photoactivatable fluorophores (PhotoTags) based on the functionalization of coumarin, fluorescein, BODIPY, rhodamine B, and cyanine dyes with a photochemically active aryl azide group. Photochemical labeling experiments using human serum albumin produced fluorescent proteins in high yields under irradiation with ultraviolet light for ArN3─a photoactivatable compound that can be radiolabeled with 89Zr for applications in optical imaging and positron emission tomography. One-pot 89Zr-radiolabeling and light-induced protein conjugation produced [89Zr]ZrDFO-RhodB-PEG3-azepin-trastuzumab. Proof-of-concept studies in vitro and in vivo confirmed that [89Zr]ZrDFO-RhodB-PEG3-azepin-trastuzumab is a potential dual-modality agent for detecting human epidermal growth factor receptor 2 (HER2/neu) expression. Overall, the PhotoTag technology represents a rapid, synthetically versatile, and user-friendly approach for generating novel protein conjugates.

Hydroxyl radical ratio type fluorescent probe as well as preparation method and application thereof

The invention relates to a novel fluorescence resonance energy transfer (FRET) probe Rho-Bob, which is constructed by connecting rhodamine B (Rho) with an N2O type benzopyrrole boron complex (Bobpy),and is used for OH ratio type fluorescence detection and imaging. Rho-Bob shows the characteristic of being sensitive to the hydrophilicity/hydrophobicity of the environment, and has excellent mitochondrial localization capability. Rho-Bob is successfully applied to intracellular .OH ratio type fluorescence imaging. The .OH can be generated by a Fenton reaction, and can also be generated by activation of intracellular drugs. The Rho-Bob probe has high selectivity and sensitivity to hydroxyl radicals, and the detection limit is as low as a nanomole level (680nM). According to the invention, .OHgenerated by artemisinin molecules in cell mitochondria is observed for the first time by using Rho-Bob, and endogenous hydroxyl radicals are found to exist in zebra fish gastrointestinal tracts (GI)under normal culture conditions for the first time. The invention not only provides the practical probe for .OH detection and imaging, but also provides an important thought for constructing novel ratiometric probes of other ROS.

Docetaxel-Loaded Fluorescent Liquid-Crystalline Nanoparticles for Cancer Theranostics

Here, we describe a novel monoolein-based cubosome formulation engineered for possible theranostic applications in oncology. The Docetaxel-loaded nanoparticles were stabilized in water by a mixture of commercial Pluronic (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer) F108 (PF108) and rhodamine- and folate-conjugated PF108 so that the nanoparticles possess targeting, therapeutic, and imaging properties. Nanoparticles were investigated by DLS, cryo-TEM, and SAXS to confirm their structural features. The fluorescent emission characterization of the proposed formulation indicated that the rhodamine conjugated to the PF108 experiences an environment less polar than water (similar to chloroform), suggesting that the fluorescent fragment is buried within the poly(ethylene oxide) corona surrounding the nanoparticle. Furthermore, these nanoparticles were successfully used to image living HeLa cells and demonstrated a significant short-term (4 h incubation) cytotoxicity effect against these cancer cells. Furthermore, given their analogy as nanocarriers for molecules of pharmaceutical interest and to better stress the singularities of these bicontinuous cubic nanoparticles, we also quantitatively evaluated the differences between cubosomes and multilamellar liposomes in terms of surface area and hydrophobic volume.