60816-17-3 Usage
Description
Cholesterol-26,26,26,27,27,27-D6, also known as Cholesterol-d6, is a stable, nonradioactive isotopic tracer of cholesterol. It is utilized in various scientific and medical applications due to its ability to mimic the behavior of natural cholesterol without the risks associated with radioactive substances. Cholesterol-d6 possesses six deuterium atoms, which differentiate it from the regular cholesterol molecule, allowing for accurate tracking and measurement in experiments.
Uses
Used in Clinical Research:
Cholesterol-26,26,26,27,27,27-D6 is used as a stable isotopic tracer for clinical research purposes. It is particularly useful in measuring the percentage of cholesterol absorption in the human body. This application is based on the work of D. B. Zilversmit (1972), who pioneered the use of Cholesterol-d6 in safe procedures to facilitate clinical investigation.
Used in Nutritional Studies:
In the field of nutrition, Cholesterol-26,26,26,27,27,27-D6 is used as a research tool to study the effects of diet on cholesterol absorption and metabolism. By tracking the absorption of Cholesterol-d6 in individuals, researchers can gain insights into the impact of different dietary components on cholesterol levels and overall health.
Used in Pharmaceutical Development:
Cholesterol-26,26,26,27,27,27-D6 is also employed in the development of pharmaceuticals targeting cholesterol-related conditions. Its stable isotopic nature allows for the precise measurement of drug effects on cholesterol metabolism, aiding in the design and optimization of novel therapeutic agents.
Used in Lipid Metabolism Research:
Cholesterol-26,26,26,27,27,27-D6 serves as a valuable tool in the study of lipid metabolism. Researchers can use this stable isotopic tracer to investigate the complex pathways involved in lipid synthesis, transport, and breakdown, contributing to a better understanding of lipid-related diseases and their potential treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 60816-17-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,8,1 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 60816-17:
(7*6)+(6*0)+(5*8)+(4*1)+(3*6)+(2*1)+(1*7)=113
113 % 10 = 3
So 60816-17-3 is a valid CAS Registry Number.
60816-17-3Relevant articles and documents
Biosynthesis of steroidal alkaloids in Solanaceae plants: Involvement of an aldehyde intermediate during C-26 amination
Ohyama, Kiyoshi,Okawa, Akiko,Moriuchi, Yuka,Fujimoto, Yoshinori
, p. 26 - 31 (2013/08/25)
The C-26 amino group of steroidal alkaloids, such as tomatine, is introduced during an early step of their biosynthesis from cholesterol. In the present study, the mechanism of C-26 amination was reinvestigated by administering stable isotope labeled compounds, such as (26,26,26,27,27,27- 2H6)cholesterol during biosynthesis of tomatine, solanine and solasonine. The chemical compositions of tomatine and solanine so obtained were analyzed by LC-MS after administering the d6-cholesterol to a tomato seedling and a potato shoot, respectively. The resulting spectra indicated that two deuterium atoms were eliminated from C-26 of cholesterol during biosynthesis. Furthermore, administration of (6-13C 2H3)mevalonate in combination with lovastatin to an eggplant seedling, followed by GC-MS analysis of solasodine after TMS derivatization established that two deuterium atoms were eliminated from C-26 of cholesterol during solasonine biosynthesis. These findings are in contrast to an earlier observation that one hydrogen atom was lost from C-26 during tomatidine biosynthesis, and suggest that C-26 nitrogen atom addition involves an aldehyde intermediate. Thus, it is proposed that the C-26 amination reaction that occurs during steroidal alkaloid biosynthesis proceeds by way of a transamination mechanism.
