60824-64-8

Basic information

• Product Name: Phenol, 2,6-dimethoxy-4-(methoxymethyl)-
• CAS NO: 60824-64-8
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Mol File: 60824-64-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phenol, 2,6-dimethoxy-4-(methoxymethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2,6-dimethoxy-4-(methoxymethyl)-(60824-64-8)
• EPA Substance Registry System: Phenol, 2,6-dimethoxy-4-(methoxymethyl)-(60824-64-8)

Safety Data

• Hazardous Substances Data: 60824-64-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 530-56-3 syringic alcohol 
• 134-96-3 syringic aldehyde 
• 685886-67-3 [2,6-dimethoxy-4-(methoxymethyl)phenyl]boronic acid 
• 6638-05-7 2,6-dimethoxy-4-methylphenol 
• 111-27-3 hexan-1-ol 
• 60824-63-7 3-methoxy-5-methyl-[1,2]benzoquinone 

Downstream Products

• 1387636-54-5 C₂₀H₂₀N₂O₆ 
• 1387636-72-7 C₃₀H₃₈N₂O₅ 
• 1387636-73-8 C₂₈H₃₆N₂O₅ 
• 1387636-74-9 C₂₉H₃₆N₂O₅ 
• 1387636-75-0 C₂₇H₃₄N₂O₅ 
• 1387636-76-1 C₂₅H₃₂N₂O₄ 
• 1387636-77-2 C₂₆H₃₂N₂O₄ 
• 1387636-78-3 C₂₈H₃₁N₃O₄ 
• 1387636-79-4 C₂₄H₃₀N₂O₄ 
• 134-96-3 syringic aldehyde 
• 1395411-54-7 C₂₁H₂₂N₂O₆ 
• 73569-69-4 1-methylmethoxy-3,5-dimethoxybenzene 
• 4179-19-5 1,3-dimethoxy-5-methylbenzene 
• 22976-41-6 3,5,3',5'-tetramethoxy-bibenzyl 

Relevant articles and documents

Nickel-catalyzed intelligent reductive transformation of the aldehyde group using hydrogen

The selective transformation of the aldehyde group (-CHO) in multifunctional oxygenates is a key challenge in the development of sustainable biomass feedstock. Herein, a smart Ni-MFC catalyst was developed from a 2D Ni-based metal-organic framework (MOF), which efficiently promoted the transformation of -CHO in the presence of H2 to a methyl group (-CH3) via the reductive etherification and hydrogenolysis of the C-O ether bond in methanol. Moreover, the catalytic process could be controlled to directionally produce methyl ether (-CH2OR) using the reductive etherification protocol. For the catalytic reduction of vanillin, the Ni-MFC-700 catalyst guaranteed the full conversion of vanillin and 96.5% yield of the desired 2-methoxy-4-methylphenol (MMP), while the Ni-MFC-500 catalyst afforded about 82.7% yield of 4-(methoxymethyl)-2-methoxyphenol in methanol solvent. This is a novel and promising approach for the valorization of multifunctional oxygenates and biomass-derived platform compounds.

Selective oxidation of phenols to hydroxybenzaldehydes and benzoquinones with dioxygen catalyzed by polymer-supported copper

Oxidation of 2,6-disubstituted 4-methylphenols with dioxygen by using a CuCl2-poly(4-methyl-4′-vinyl-2,2′-bipyridine) catalyst gave the corresponding 4-hydroxybenzaldehydes in high yields. The activity of the catalyst and the selectivity of the products significantly depended on the reaction conditions and the composition of the catalyst. When the molar ratio of the bipyridine unit of the polymer ligand to Cu was unity, i.e., N/Cu = 2, the best results were obtained. Moreover, the reaction is likely to be promoted by coordination of the products to the catalyst. Similarly, 2,3,6-trimethylphenol and related compounds were converted to p-benzoquinones selectively with a CuCl2-poly(4-vinylpyridine) catalyst. These polymer-supported catalysts were readily recovered and are reusable without noticeable decrease of their activity.