60890-27-9

Basic information

• Product Name: (±)-Ruspolinone
• Synonyms: (±)-Ruspolinone;Ruspolinone
• CAS NO: 60890-27-9
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.30556
• Mol File: 60890-27-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 388.4°Cat760mmHg
• Flash Point: 188.7°C
• Appearance: /
• Density: 1.085g/cm³
• Vapor Pressure: 3.07E-06mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: (±)-Ruspolinone(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-Ruspolinone(60890-27-9)
• EPA Substance Registry System: (±)-Ruspolinone(60890-27-9)

Safety Data

• Hazardous Substances Data: 60890-27-9(Hazardous Substances Data)

Usage

General Description

(±)-Ruspolinone is a natural product isolated from the marine fungus Ascochyta salicorniae, which has been reported to possess various biological activities. It belongs to the class of polyketides and exhibits a unique chemical structure featuring a polyene system. Studies have shown that (±)-Ruspolinone has significant antioxidant properties and is capable of inhibiting the production of nitric oxide in cells, suggesting potential therapeutic applications for conditions characterized by oxidative stress and inflammation. Additionally, it has been found to exhibit moderate cytotoxicity against certain cancer cell lines, making it a promising candidate for further research in the development of anticancer drugs. The distinct chemical structure and biological activities of (±)-Ruspolinone make it an interesting target for pharmaceutical and biomedical research.

InChI:InChI=1/C14H19NO3/c1-17-13-6-5-10(8-14(13)18-2)12(16)9-11-4-3-7-15-11/h5-6,8,11,15H,3-4,7,9H2,1-2H3

Upstream product

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• 74053-93-3 methyl 3-(3,4-dimethoxyphenyl)-3-oxopropionate 
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Downstream Products

• 76787-77-4 1-(3,4-Dimethoxyphenyl)-2-<1-<(3,4-dimethoxyphenyl)acetyl>pyrrolidin-2-yl>ethanone 
• 67257-60-7 (+/-)-N-Acetyl-ruspolinon 
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• 26503-67-3 (+/-)-6,7-di(3,4-dimethoxyphenyl)-1,2,3,5,8,8a-hexahydro-indolizine 
• 1236770-99-2 1-(3,4-dimethoxyphenyl)-2-(1-(2-(4-methoxyphenyl)ethan-oyl)pyrrolidin-2-yl)ethanone 

Relevant articles and documents

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

Heterocycles based on piperidine and pyrrolidine are key moieties in natural products and pharmaceutically active molecules. A novel multi-enzymatic approach based on the combination of a lipase with an α,ω-diamine transaminase is reported, opening up the synthesis, isolation and characterisation of a broad range of 2-substituted N-heterocycle alkaloids.

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