60901-22-6

Basic information

• Product Name: 3-(2-phenylethenyl)benzoic acid
• CAS NO: 60901-22-6
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.2546
• Mol File: 60901-22-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 409.8°C at 760 mmHg
• Flash Point: 187.2°C
• Density: 1.211g/cm³
• Vapor Pressure: 1.89E-07mmHg at 25°C
• Refractive Index: 1.687
• CAS DataBase Reference: 3-(2-phenylethenyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-phenylethenyl)benzoic acid(60901-22-6)
• EPA Substance Registry System: 3-(2-phenylethenyl)benzoic acid(60901-22-6)

Safety Data

• Hazardous Substances Data: 60901-22-6(Hazardous Substances Data)

Upstream product

• 25692-41-5 methyl 3-styrylbenzoate 
• 618-89-3 methyl 3-bromobenzoate 
• 78782-27-1 4,4,5,5-tetramethyl-2-styryl-[1,3,2]dioxaborolane 
• 124-38-9 carbon dioxide 
• 24942-77-6 1-chloro-3-styrylbenzene 
• 100-42-5 styrene 
• 618-51-9 3-Iodobenzoic acid 
• 65-85-0 benzoic acid 

Downstream Products

• 588-59-0 stilbene 

Relevant articles and documents

Highly-chemoselective step-down reduction of carboxylic acids to aromatic hydrocarbons: Via palladium catalysis

Aryl carboxylic acids are among the most abundant substrates in chemical synthesis and represent a perfect example of a traceless directing group that is central to many processes in the preparation of pharmaceuticals, natural products and polymers. Herein, we describe a highly selective method for the direct step-down reduction of carboxylic acids to arenes, proceeding via well-defined Pd(0)/(ii) catalytic cycle. The method shows a remarkably broad substrate scope, enabling to direct the classical acyl reduction towards selective decarbonylation by a redox-neutral mechanism. The utility of this reaction is highlighted in the direct defunctionalization of pharmaceuticals and natural products, and further emphasized in a range of traceless processes using removable carboxylic acids under mild, redox-neutral conditions orthogonal to protodecarboxylation. Extensive DFT computations were conducted to demonstrate preferred selectivity for the reversible oxidative addition and indicated that a versatile hydrogen atom transfer (HAT) pathway is operable.

Alpha-helical mimetics

Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.